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EGFR-Mutated Lung Cancer With T790M-Acquired Resistance in the Brain and Histologic Transformation in the Lung

Kevin S. Scher, Juan-Sebastian Saldivar, Michael Fishbein, Alberto Marchevsky, and Karen L. Reckamp

This case report describes the rare occurrence of a T790M resistance mutation found in a central nervous system (CNS) parenchymal metastasis. A concomitant squamous histology transformation in a lung non-T790M-resistant metastasis is also described. The authors hypothesize that this CNS resistance and histology transformation may have resulted from intermittent use of erlotinib treatment. This case report emphasizes the complexities of using erlotinib in the induction setting.

Cover Journal of the National Comprehensive Cancer Network

In Journal of the National Comprehensive Cancer Network Volume 11 (2013): Issue 9 (Sep 2013)

Sep 2013
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QIM22-198: Optimizing a Systemic Platform to Standardize Oncologic Biosimilars Utilization at Cedars-Sinai Medical Center (CSMC)

Suwicha Limvorasak, Hilary Teaford, Crystal Leung Dobbs, Kyung Kim, Marcio A. Diniz, Andre Rogatko, Edwin M. Posadas, Kevin S. Scher, Vipul Patel, Bruce Vinson, Leanne Sakamoto, Rita Shane, Robert A. Figlin, and Karen L. Reckamp

Cover Journal of the National Comprehensive Cancer Network

In Journal of the National Comprehensive Cancer Network Volume 20 (2022): Issue 3.5 (Mar 2022): Abstracts from the NCCN 2022 Virtual Annual Conference

31 Mar 2022