NCCN Task Force Report: Management of Dermatologic and Other Toxicities Associated With EGFR Inhibition in Patients With Cancer

Authors:
Barbara Burtness
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 MD
,
Milan Anadkat
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 MD
,
Surendra Basti
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 MD
,
Miranda Hughes
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 PhD
,
Mario E. Lacouture
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 MD
,
Joan S. McClure
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 MS
,
Patricia L. Myskowski
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 MD
,
Jennifer Paul
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 PA-C
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Clifford S. Perlis
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 MD, MBe
,
Leonard Saltz
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 MD
, and
Sharon Spencer
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 MD
Volume/Issue:
Volume 7: Issue Suppl_1
Online Publication Date:
May 2009
DOI:
https://doi.org/10.6004/jnccn.2009.0074
Restricted access

This NCCN Task Force Report describes the management of dermatologic and ocular toxicities that occur in patients treated with epidermal growth factor receptor (EGFR) inhibitors. Task force members are from NCCN member institutions and include oncologists, dermatologists, an ophthalmologist, and a mid-level oncology provider. This report describes commonly used therapies that the task force agreed are appropriate standards of care for dermatologic and ophthalmologic toxicities associated with EGFR inhibitors, which generally are supported only by anecdotal evidence. Few recommendations are evidence based; however, some commonly used therapies have data supporting their use. Conclusions from completed clinical trials are generally limited by the small numbers of patients enrolled. The information in this report is based on available published data on treating toxicities associated with EGFR inhibitors, data from treatment of clinically similar toxicities from different etiologies, and expert opinion among the NCCN Task Force members.

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Copyright:
Copyright © 2009 by the National Comprehensive Cancer Network 2009
Article Category:
Research Article
Print Publication Date:
01 May 2009
Online Publication Date:
May 2009
Keywords:
Dermatologic toxicities; ocular toxicities; rash; acne-like rash; papulopustular rash; dry eye; paronychia; radiation dermatitis; epidermal growth factor receptor; EGFR; EGFR inhibitor; tyrosine kinase inhibitors; TKI; cetuximab; panitumumab; erlotinib; gefitinib; colorectal cancer; head and neck cancer; non–small cell lung cancer
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