NCCN Task Force Report: Adjuvant Therapy for Breast Cancer

Authors:
Robert W. Carlson
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 MD
,
Elizabeth Brown
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 MD
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Harold J. Burstein
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 MD, PhD
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William J. Gradishar
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 MD
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Clifford A. Hudis
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 MD
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Charles Loprinzi
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 MD
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Eleftherios Paul Mamounas
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 MD
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Edith A. Perez
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 MD
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Kathleen Pritchard
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 MD, FRCPC
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Peter Ravdin
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 MD
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Abram Recht
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 MD
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George Somlo
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 MD
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Richard L. Theriault
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 DO, MBA
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Eric P. Winer
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 MD
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Antonio C. Wolff
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 MD
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for the NCCN Adjuvant Therapy for Breast Cancer Task Force
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Volume/Issue:
Volume 4: Issue S1
Online Publication Date:
Apr 2006
DOI:
https://doi.org/10.6004/jnccn.2006.2001
Restricted access

Abstract

The National Comprehensive Cancer Network (NCCN) first published the NCCN Breast Cancer Treatment Guidelines in 1996. The Guidelines address the treatment of all stages of breast cancer across the spectrum of patient care and have been updated yearly. Adjuvant therapy for breast cancer has undergone an especially rapid evolution over the past few years. Therefore, the NCCN Breast Cancer Guidelines Panel was supplemented by additional experts to form the Adjuvant Therapy Task Force to provide a forum for an extended discussion and expanded input to the adjuvant therapy recommendations for the Breast Cancer Treatment Guidelines. Issues discussed included methods of risk-stratification for recurrence; how biologic markers such as HER2 status, quantitative estrogen receptor, or genetic markers can be incorporated as prognostic or predictive factors; and how age, menopausal status, and estrogen receptor levels impact benefits from chemotherapy and endocrine therapy. Additionally, the task force discussed the strategies for use of aromatase inhibitors in postmenopausal women and the potential incorporation of trastuzumab into adjuvant therapy of women with HER2/neu positive breast cancer. This supplement summarizes the background data and ensuing discussion from the Adjvuant Task Force meeting. (JNCCN 2006;4[suppl 1]:S-1–S-26)

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Print ISSN:
1540-1405
Online ISSN:
1540-1413
Publisher:
National Comprehensive Cancer Network
Cover Journal of the National Comprehensive Cancer Network
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Copyright:
Copyright © 2006 by the National Comprehensive Cancer Network 2006
Article Category:
Research Article
Print Publication Date:
01 Apr 2006
Online Publication Date:
Apr 2006
Keywords:
NCCN Clinical Practice Guidelines in Oncology; breast cancer; adjuvant therapy; risk of recurrence; hormone therapy; ER+; estrogen receptors; HER2; aromatase inhibitors; prognostic factors; taxanes; gene expression profiling

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