Strategies for the Treatment of Acute Promyelocytic Leukemia

The outcome of acute promyelocytic leukemia (APL) has improved dramatically during the past 40 years. Insights into the genetic and biologic mechanisms of APL lead to the development of specific and effective therapeutic strategies. This article discusses the therapeutic interventions that transformed APL from one of the most lethal leukemias to one that is highly curable.

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Correspondence: Olga Frankfurt, MD, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Care Center of Northwestern University, 676 North St. Clair Street, Suite 850, Chicago, IL 60611. E-mail: o-frankfurt@northwestern.edu

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