New Tools for Breast Cancer Risk Assessment

Presented by:
Sagar Sardesai
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 MD, MPH
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With the incidence of breast cancer rising steadily every year, research into methods for assessing and reducing the risk of developing this disease has been increasing to match this unmet need. This review highlights the use and limitations of breast cancer risk assessment methods commonly employed in high-risk clinics to identify at-risk individuals who will benefit from multi-gene panel germline testing, enhanced cancer screenings, lifestyle interventions, and risk-reducing therapeutic agents or surgeries.

Disclosures: Dr. Sardesai has disclosed receiving consulting fees from AstraZeneca Pharmaceuticals LP, Gilead Sciences, Inc., and Stemline Therapeutics, Inc.

Correspondence: Sagar Sardesai, MD, MPH, The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute, 1800 Cannon Drive, Suite 1335 Lincoln Tower, Columbus, OH 43210. Email: sagar.sardesai@osumc.edu
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  • 1.

    American Cancer Society. Cancer Facts & Figures 2016. Accessed March 24, 2025. Available at: https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2016.html

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Daly MB, Pal T, AlHilli Z, et al. NCCN Clinical Practice Guidelines in Oncology: Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate. Version 3.2025. Accessed March 24, 2025. To view the most recent version, visit https://www.nccn.org

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Neuhouser ML, Aragaki AK, Prentice RL, et al. Overweight, obesity, and postmenopausal invasive breast cancer risk: a secondary analysis of the Women’s Health Initiative randomized clinical trials. JAMA Oncol 2015; 1:611621.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Wu Y, Zhang D, Kang S. Physical activity and risk of breast cancer: a meta-analysis of prospective studies. Breast Cancer Res Treat 2013;137:869882.

  • 5.

    Rock CL, Thomson C, Gansler T, et al. American Cancer Society guideline for diet and physical activity for cancer prevention. CA Cancer J Clin 2020;70:245271.

  • 6.

    Gail MH, Brinton LA, Byar DP, et al. Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. J Natl Cancer Inst 1989;81:18791886.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Boughey JC, Hartmann LC, Anderson SS, et al. Evaluation of the Tyrer-Cuzick (International Breast Cancer Intervention Study) model for breast cancer risk prediction in women with atypical hyperplasia. J Clin Oncol 2010;28:35913596.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Claus EB, Risch N, Thompson WD. The calculation of breast cancer risk for women with a first degree family history of ovarian cancer. Breast Cancer Res Treat 1993;28:115120.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Lee A, Mavaddat N, Wilcox AN, et al. BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors. Genet Med 2019;21:17081718.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Cuzick J, Forbes JF, Sestak I, et al. Long-term results of tamoxifen prophylaxis for breast cancer—96-month follow-up of the randomized IBIS-I trial. J Natl Cancer Inst 2007;99:272282.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Vogel VG, Costantino JP, Wickerham DL, et al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. JAMA 2006;295:27272741.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Cuzick J, Sestak I, Forbes JF, et al. Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled trial. Lancet 2014;383:10411048.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    DeCensi A, Puntoni M, Guerrieri-Gonzaga A, et al. Randomized placebo controlled trial of low-dose tamoxifen to prevent local and contralateral recurrence in breast intraepithelial neoplasia. J Clin Oncol 2019;37:16291637.

    • PubMed
    • Search Google Scholar
    • Export Citation

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