Expansion of Recommendations for Hereditary Cancers

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Kara N. Maxwell
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 MD, PhD
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Lee-may Chen
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Xavier Llor
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Heather Hampel
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 MS, CGC
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Tuya Pal
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Hereditary cancers account for up to 10% of all cancer diagnoses, and are caused by genetic mutations passed from parent to child. Emerging evidence in this field has resulted in cancer prevention and specific treatment decisions, leading to decreased cancer incidence and improved patient quality of life. However, there have been notable differences in clinical guidelines that provide inconsistent recommendations, causing confusion about what genes are of importance. The updated NCCN Guidelines for Genetic/Familial High-Risk Assessment provide the most up-to-date recommendations for not only clinicians but also patients and their family members with similar genetic mutations.

Disclosures: H. Hampel has disclosed receiving consulting fees from Carelon, Exact Sciences (PreventionGenetics), Genome Medical, GI OnDemand, and LynSight; and owning equity interest/stock options in Genome Medical and GI OnDemand. The remaining presenters have disclosed no relevant financial relationships.

Correspondence: Kara N. Maxwell, MD, PhD, Abramson Cancer Center at the University of Pennsylvania, 421 Curie Boulevard, Room 810, Philadelphia, PA 19104. Email: kara.maxwell@pennmedicine.upenn.edu;
Lee-may Chen, MD, UCSF Helen Diller Family Comprehensive Cancer Center, 490 Illinois Street, 10th Floor Box 0132, San Francisco, CA 94143. Email: lee-may.chen@ucsf.edu;
Xavier Llor, MD, PhD, Yale Cancer Center/Smilow Cancer Hospital, 333 Cedar Street/LMP 1080, Box 208019, New Haven, CT 06520. Email: xavier.llor@yale.edu;
Heather Hampel, MS, CGC, City of Hope National Medical Center, 1500 Duarte Road, Building 173, Duarte, CA 91010. Email: hhampel@coh.org; and
Tuya Pal, MD, Vanderbilt University Medical Center, 1500 21st Avenue South, Suite 2500, Nashville, TN 37212. Email: tuya.pal@vumc.org
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