NCCN Guidelines® Insights: Lung Cancer Screening, Version 1.2025

Featured Updates to the NCCN Guidelines

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Douglas E. Wood Fred Hutchinson Cancer Center

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Ella A. Kazerooni University of Michigan Rogel Cancer Center

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Denise R. Aberle UCLA Jonsson Comprehensive Cancer Center

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Christine Argento Johns Hopkins Kimmel Cancer Center

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Jonathan Baines Mayo Clinic Comprehensive Cancer Center

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Brian Boer Fred & Pamela Buffett Cancer Center

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Lisa M. Brown UC Davis Comprehensive Cancer Center

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Jessica Donington The UChicago Medicine Comprehensive Cancer Center

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Georgie A. Eapen The University of Texas MD Anderson Cancer Center

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J. Scott Ferguson University of Wisconsin Carbone Cancer Center

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Lifang Hou Robert H. Lurie Comprehensive Cancer Center of Northwestern University

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Donald Klippenstein Moffitt Cancer Center

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Ana S. Kolansky Abramson Cancer Center at the University of Pennsylvania

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Rohit Kumar Fox Chase Cancer Center

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Lorriana E. Leard UCSF Helen Diller Family Comprehensive Cancer Center

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Ann N.C. Leung Stanford Cancer Institute

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Peter Mazzone Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute

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Robert E. Merritt The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute

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Kim Norris Lung Cancer Foundation of America

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Mark Onaitis UC San Diego Moores Cancer Center

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Sudhakar Pipavath Fred Hutchinson Cancer Center

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Varun Puri Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine

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Dan Raz City of Hope National Medical Center

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Chakravarthy Reddy Huntsman Cancer Institute at the University of Utah

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Mary E. Reid Roswell Park Comprehensive Cancer Center

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Kim L. Sandler Vanderbilt-Ingram Cancer Center

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Jacob Sands Dana-Farber/Brigham and Women's Cancer Center | Mass General Cancer Center

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Matthew B. Schabath Moffitt Cancer Center

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Catherine R. Sears Indiana University Melvin and Bren Simon Comprehensive Cancer Center

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Jamie L. Studts University of Colorado Cancer Center

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Lynn Tanoue Yale Cancer Center/Smilow Cancer Hospital

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Amber L. Thacker St. Jude Children's Research Hospital/The University of Tennessee Health Science Center

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Betty C. Tong Duke Cancer Institute

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William D. Travis Memorial Sloan Kettering Cancer Center

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Benjamin Wei O’Neal Comprehensive Cancer Center at UAB

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Kenneth Westover UT Southwestern Simmons Comprehensive Cancer Center

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Beth McCullough National Comprehensive Cancer Network

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Swathi Ramakrishnan National Comprehensive Cancer Network

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The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Lung Cancer Screening provide criteria for selecting individuals for screening and offer recommendations for evaluating and managing lung nodules detected during initial and subsequent annual screening. These NCCN Guidelines Insights focus on recent updates to the NCCN Guidelines for Lung Cancer Screening.

Provided content development and/or authorship assistance

Douglas E. Wood, Ella A. Kazerooni, Lorriana E. Leard, Matthew B. Schabath, Jamie L. Studts, Beth McCullough, and Swathi Ramakrishnan

The full and most current version of these NCCN Guidelines is available at NCCN.org.

NCCN CATEGORIES OF EVIDENCE AND CONSENSUS

Category 1: Based upon high-level evidence (≥1 randomized phase 3 trials or high-quality, robust meta-analyses), there is uniform NCCN consensus (≥85% support of the Panel) that the intervention is appropriate.

Category 2A: Based upon lower-level evidence, there is uniform NCCN consensus (≥85% support of the Panel) that the intervention is appropriate.

Category 2B: Based upon lower-level evidence, there is NCCN consensus (≥50%, but <85% support of the Panel) that the intervention is appropriate.

Category 3: Based upon any level of evidence, there is major NCCN disagreement that the intervention is appropriate.

All recommendations are category 2A unless otherwise indicated.

NCCN CATEGORIES OF PREFERENCE

Preferred intervention: Interventions that are based on superior efficacy, safety, and evidence; and, when appropriate, affordability.

Other recommended intervention: Other interventions that may be somewhat less efficacious, more toxic, or based on less mature data; or significantly less affordable for similar outcomes.

Useful in certain circumstances: Other interventions that may be used for selected patient populations (defined with recommendation).

All recommendations are considered appropriate.

NCCN recognizes the importance of clinical trials and encourages participation when applicable and available. Trials should be designed to maximize inclusiveness and broad representative enrollment.

PLEASE NOTE

The NCCN Guidelines® are a statement of evidence and consensus of the authors regarding their views of currently accepted approaches to treatment.

The NCCN Guidelines® Insights highlight important changes in the NCCN Guidelines® recommendations from previous versions. Colored markings in the algorithm show changes and the discussion aims to further understanding of these changes by summarizing salient portions of the panel’s discussion, including the literature reviewed.

The NCCN Guidelines Insights do not represent the full NCCN Guidelines; further, the National Comprehensive Cancer Network® (NCCN®) makes no representations or warranties of any kind regarding the content, use, or application of the NCCN Guidelines and NCCN Guidelines Insights and disclaims any responsibility for their application or use in any way.

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