Updates in the Management of Neuroblastoma

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Rochelle Bagatell
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Treatment of children with neuroblastoma depends on accurate assessment of the risk of relapse. Factors used in risk stratification for patients with neuroblastoma include disease stage, MYCN amplification status, age, tumor histology, presence or absence of segmental chromosome aberrations, and tumor cell ploidy. The goal of treatment for patients with low-risk neuroblastoma is cure with minimal toxicity. However, for those with high-risk neuroblastoma, the treatment approach involves multiple therapeutic modalities, including multi-agent chemotherapy at conventional doses, surgery, high-dose chemotherapy with autologous stem cell rescue, external-beam radiotherapy, a differentiating agent, and immunotherapy. Multidisciplinary collaboration is essential for optimal care.

Disclosures: Dr. Bagatell has disclosed no relevant financial relationships.

Correspondence: Rochelle Bagatell, MD, Children’s Hospital of Philadelphia, 3500 Civic Center Boulevard, Room 3524, Philadelphia, PA 19104. Email: bagatellr@chop.edu
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