Management of Renal Cell Carcinoma

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Michael Serzan
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Immune checkpoint inhibitor therapy has served as the foundation of therapy for a majority of patients with advanced renal cell carcinoma (RCC). For patients with metastatic clear cell RCC, there are several immunotherapy-based combinations that have demonstrated robust long-term outcomes. Selection of the ideal combination for each individual patient requires nuanced strategies that are highlighted in NCCN Guidelines. More recently, data have emerged showing benefit of immune checkpoint inhibitors for patients with variant histologies. Lastly, pembrolizumab has been approved in the adjuvant setting for patients with clear cell RCC who are at high risk of recurrence after nephrectomy.

Disclosures: Dr. Serzan has disclosed no relevant financial relationships.

Correspondence: Michael Serzan, MD, Dana-Farber Cancer Institute, 450 Brookline Avenue, Dana 927, Boston, MA 02215. Email: michael_serzan@dfci.harvard.edu
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  • 1.

    Choueiri TK, Tomczak P, Park SH, et al. Pembrolizumab versus placebo as post-nephrectomy adjuvant therapy for patients with renal cell carcinoma: randomized, double-blind, phase III KEYNOTE-564 study. J Clin Oncol 2021;39(Suppl):Abstract LBA5.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Berg SA, McGregor BA. Adjuvant immunotherapy in resected renal cell carcinoma: déjà vu or progress? ASCO Daily News. Published February 9, 2023. Available at: https://dailynews.ascopubs.org/do/adjuvant-immunotherapy-resected-renal-cell-carcinoma-deja-vu-progress

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    US Food and Drug Administration. FDA approved pembrolizumab for adjuvant treatment of renal cell carcinoma. Accessed April 8, 2024. Available at: https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-pembrolizumab-adjuvant-treatment-renal-cell-carcinoma

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Motzer RJ, Jonasch E, Agarwal N, et al. NCCN Clinical Practice Guidelines in Oncology: Kidney Cancer. Version 3.2024. Accessed April 8, 2024. To view the most recent version, visit https://www.nccn.org

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Choueiri TK, Halabi S, Sanford BL, et al. Cabozantinib versus sunitinib as initial targeted therapy for patients with metastatic renal cell carcinoma of poor or intermediate risk: the Alliance A031203 CABOSUN trial. J Clin Oncol 2017;35:591597.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Tannir NM, Escudier B, McDermott DF, et al. Nivolumab plus ipilimumab vs sunitinib for first-line treatment of advanced renal cell carcinoma: long-term follow-up data from the phase 3 CheckMate 214 trial. J Clin Oncol 2024;42(Suppl):Abstract 363.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Rini BI, Plimack ER, Stus V, et al. Pembrolizumab plus axitinib versus sunitinib for advanced renal-cell carcinoma. N Engl J Med 2019;380:11161127.

  • 8.

    Choueiri TK, Powles T, Burotto M, et al. Nivolumab plus cabozantinib versus sunitinib for advanced renal-cell carcinoma. N Engl J Med 2021;384:829841.

  • 9.

    Motzer RJ, Porta C, Alekseev B, et al. Health-related quality-of-life analysis from the phase 3 CLEAR trial of lenvatinib plus pembrolizumab or everolimus versus sunitinib for patients with advanced renal cell carcinoma. J Clin Oncol 2021;39(Suppl):Abstract 4502.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Choueiri TK, Powles T, Albiges L, et al. Cabozantinib plus nivolumab and ipilimumab in renal-cell carcinoma. N Engl J Med 2023;388:17671778.

  • 11.

    Pal SK, Albiges L, Tomczak P, et al. Atezolizumab plus cabozantinib versus cabozantinib monotherapy for patients with renal cell carcinoma after progression with previous immune checkpoint inhibitor treatment (CONTACT-03): a multicentre, randomised, open-label, phase 3 trial. Lancet 2023;402:185195.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Choueiri TK, Escudier B, Powles T, et al. Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial. Lancet Oncol 2016;17:917927.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Albiges L, Schmidinger M, Taguieva-Pioger N, et al. CaboPoint: a phase II study of cabozantinib as second-line treatment in patients with metastatic renal cell carcinoma. Future Oncol 2022;18:915926.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Procopio G, Claps M, Pircher C, et al. A multicenter phase 2 single arm study of cabozantinib in patients with advanced or unresectable renal cell carcinoma pre-treated with one immune-checkpoint inhibitor: the BREAKPOINT trial (Meet-Uro trial 03). Tumori 2023;109:129137.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Albiges L, Rini BI, Peltola K, et al. LBA88 Belzutifan versus everolimus in participants (pts) with previously treated advanced renal cell carcinoma (RCC): patient-reported outcomes (PROs) in the phase 3 LITESPARK-005 study. Ann Oncol 2023;34(Suppl 2):S13291330.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Choueiri TK, Bauer T, Merchan JR, et al. LBA87 Phase II LITESPARK-003 study of belzutifan in combination with cabozantinib for advanced clear cell renal cell carcinoma. Ann Oncol 2023;34(Suppl 2):S13281329.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Albiges L, Gurney H, Atduev V, et al. Pembrolizumab plus lenvatinib as first-line therapy for advanced non-clear-cell renal cell carcinoma (KEYNOTE-B61): a single-arm, multicentre, phase 2 trial. Lancet Oncol 2023;24:881891.

    • PubMed
    • Search Google Scholar
    • Export Citation

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