NCCN Guidelines® Insights: Survivorship, Version 2.2024

Featured Updates to the NCCN Guidelines

Authors:
Tara Sanft Yale Cancer Center/Smilow Cancer Hospital

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Andrew T. Day UT Southwestern Simmons Comprehensive Cancer Center

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Mindy Goldman UCSF Helen Diller Family Comprehensive Cancer Center

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Shannon Ansbaugh Patient Advocate

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Saro Armenian City of Hope National Medical Center

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K. Scott Baker Fred Hutchinson Cancer Center

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Tarah J. Ballinger Indiana University Melvin and Bren Simon Comprehensive Cancer Center

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Wendy Demark-Wahnefried O’Neal Comprehensive Cancer Center at UAB

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Nathan Paul Fairman UC Davis Comprehensive Cancer Center

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Josephine Feliciano Johns Hopkins Kimmel Cancer Center

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Tessa Faye Flores Roswell Park Comprehensive Cancer Center

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Debra L. Friedman Vanderbilt-Ingram Cancer Center

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Nicolette Gabel University of Michigan Rogel Cancer Center

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Christine Hill-Kayser Abramson Cancer Center at the University of Pennsylvania

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Divya Koura UC San Diego Moores Cancer Center

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Kimberley Lee Moffitt Cancer Center

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Nita Lee The UChicago Medicine Comprehensive Cancer Center

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Allison L. McDonough Mass General Cancer Center

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Michelle Melisko UCSF Helen Diller Family Comprehensive Cancer Center

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Kathi Mooney Huntsman Cancer Institute at the University of Utah

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Halle C.F. Moore Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute

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Natalie Moryl Memorial Sloan Kettering Cancer Center

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Heather Neuman University of Wisconsin Carbone Cancer Center

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Linda Overholser University of Colorado Cancer Center

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Chirayu Patel Mass General Cancer Center

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Lindsay Peterson Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine

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William Pirl Dana-Farber/Brigham and Women’s Cancer Center

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Andrea Porpiglia Fox Chase Cancer Center

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Lidia Schapira Stanford Cancer Institute

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Anna Schwartz Fred & Pamela Buffett Cancer Center

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Sophia Smith Duke Cancer Institute

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Amye Tevaarwerk Mayo Clinic Comprehensive Cancer Center

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Diane Von Ah The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute

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Robert Wake The University of Tennessee Health Science Center

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Eric Yang UCLA Jonsson Comprehensive Cancer Center

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Phyllis Zee Robert H. Lurie Comprehensive Cancer Center of Northwestern University

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Nicole McMillian National Comprehensive Cancer Network

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Deborah Freedman-Cass National Comprehensive Cancer Network

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The NCCN Guidelines for Survivorship include recommendations for screening, evaluation, and treatment of psychosocial and physical problems resulting from adult-onset cancer and its treatment. They also include recommendations to promote healthy behaviors and immunizations in survivors and provide a framework for care coordination. These NCCN Guidelines Insights summarize the panel’s current recommendations regarding sexual health and fertility.

Provided content development and/or authorship assistance

Tara Sanft, Andrew T. Day, K. Scott Baker, Christine Hill-Kayser, Nita Lee, Mindy Goldman, Kathi Mooney, Halle Moore, Amye Tevaarwerk, Nicole McMillian, and Deborah Freedman-Cass

The full and most current version of these NCCN Guidelines is available at NCCN.org.

NCCN CATEGORIES OF EVIDENCE AND CONSENSUS

Category 1: Based upon high-level evidence (≥1 randomized phase 3 trials or high-quality, robust meta-analyses), there is uniform NCCN consensus (≥85% support of the Panel) that the intervention is appropriate.

Category 2A: Based upon lower-level evidence, there is uniform NCCN consensus (≥85% support of the Panel) that the intervention is appropriate.

Category 2B: Based upon lower-level evidence, there is NCCN consensus (≥50%, but <85% support of the Panel) that the intervention is appropriate.

Category 3: Based upon any level of evidence, there is major NCCN disagreement that the intervention is appropriate.

All recommendations are category 2A unless otherwise indicated.

NCCN CATEGORIES OF PREFERENCE

Preferred intervention: Interventions that are based on superior efficacy, safety, and evidence; and, when appropriate, affordability.

Other recommended intervention: Other interventions that may be somewhat less efficacious, more toxic, or based on less mature data; or significantly less affordable for similar outcomes.

Useful in certain circumstances: Other interventions that may be used for selected patient populations (defined with recommendation).

All recommendations are considered appropriate.

NCCN recognizes the importance of clinical trials and encourages participation when applicable and available. Trials should be designed to maximize inclusiveness and broad representative enrollment.

PLEASE NOTE

The NCCN Guidelines® are a statement of evidence and consensus of the authors regarding their views of currently accepted approaches to treatment.

The NCCN Guidelines® Insights highlight important changes in the NCCN Guidelines® recommendations from previous versions. Colored markings in the algorithm show changes and the discussion aims to further understanding of these changes by summarizing salient portions of the panel’s discussion, including the literature reviewed.

The NCCN Guidelines Insights do not represent the full NCCN Guidelines; further, the National Comprehensive Cancer Network® (NCCN®) makes no representations or warranties of any kind regarding the content, use, or application of the NCCN Guidelines and NCCN Guidelines Insights and disclaims any responsibility for their application or use in any way.

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