Mesothelioma: Peritoneal, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology

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David S. Ettinger The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

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Douglas E. Wood Fred Hutchinson Cancer Center

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Joe Y. Chang The University of Texas MD Anderson Cancer Center

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Mesothelioma is a rare cancer originating in mesothelial surfaces of the peritoneum, pleura, and other sites. These NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) focus on peritoneal mesothelioma (PeM). The NCCN Guidelines for PeM provide recommendations for workup, diagnosis, and treatment of primary as well as previously treated PeM. The diagnosis of PeM may be delayed because PeM mimics other diseases and conditions and because the disease is so rare. The pathology section was recently updated to include new information about markers used to identify mesothelioma, which is difficult to diagnose. The term “malignant” is no longer used to classify mesotheliomas, because all mesotheliomas are now defined as malignant.

Individual Disclosures for the Mesothelioma: Peritoneal Panel
Individual Disclosures for the Mesothelioma: Peritoneal Panel

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  • 1.

    Noone AM, Howlader N, Krapcho M, et al. SEER cancer statistics review (CSR), 1975–2015. Accessed April 1, 2023. Available at: https://seer.cancer.gov/archive/csr/1975_2015/

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    American Cancer Association. Special section: rare cancers in adults. Accessed April 1, 2023. Available at: https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2017/cancer-facts-and-figures-2017-special-section-rare-cancers-in-adults.pdf

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Price B, Ware A. Time trend of mesothelioma incidence in the United States and projection of future cases: an update based on SEER data for 1973 through 2005. Crit Rev Toxicol 2009;39:576588.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Tsao AS, Wistuba I, Roth JA, et al. Malignant pleural mesothelioma. J Clin Oncol 2009;27:20812090.

  • 5.

    National Cancer Institute. Interactive tools, maps, & graphs: SEER* Explorer. Accessed April 1, 2023. Available at: https://seer.cancer.gov/statistics/interactive.html

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Grogg JB, Fronzaroli JN, Oliveira P, et al. Clinicopathological characteristics and outcomes in men with mesothelioma of the tunica vaginalis testis: analysis of published case-series data. J Cancer Res Clin Oncol 2021;147:26712679.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Carteni G, Manegold C, Garcia GM, et al. Malignant peritoneal mesothelioma—results from the International Expanded Access Program using pemetrexed alone or in combination with a platinum agent. Lung Cancer 2009;64:211218.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Mirarabshahii P, Pillai K, Chua TC, et al. Diffuse malignant peritoneal mesothelioma—an update on treatment. Cancer Treat Rev 2012;38:605612.

  • 9.

    Chekol SS, Sun CC. Malignant mesothelioma of the tunica vaginalis testis: diagnostic studies and differential diagnosis. Arch Pathol Lab Med 2012;136:113117.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Henley SJ, Peipins LA, Rim SH, et al. Geographic co-occurrence of mesothelioma and ovarian cancer incidence. J Womens Health (Larchmt) 2020;29:111118.

  • 11.

    Ullah A, Waheed A, Khan J, et al. Incidence, survival analysis and future perspective of primary peritoneal mesothelioma (PPM): a population-based study from SEER database. Cancers (Basel) 2022;14:942.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Kusamura S, Baratti D, De Simone M, et al. Diagnostic and therapeutic pathway in diffuse malignant peritoneal mesothelioma. Cancers (Basel) 2023;15:662.

  • 13.

    Bijelic L, Darcy K, Stodghill J, et al. Predictors and outcomes of surgery in peritoneal mesothelioma: an analysis of 2000 patients from the National Cancer Database. Ann Surg Oncol 2020;27:29742982.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Acs M, Gerken M, Gajic I, et al. Ten-year single-center experience with treatment of primary diffuse malignant peritoneal mesothelioma (DMPM) by cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Langenbecks Arch Surg 2022;407:30573067.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Chapel DB, Schulte JJ, Absenger G, et al. Malignant peritoneal mesothelioma: prognostic significance of clinical and pathologic parameters and validation of a nuclear-grading system in a multi-institutional series of 225 cases. Mod Pathol 2021;34:380395.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Helm JH, Miura JT, Glenn JA, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: a systematic review and meta-analysis. Ann Surg Oncol 2015;22:16861693.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Husain AN, Colby TV, Ordóñez NG, et al. Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 update of the consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med 2018;142:89108.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18.

    Galateau-Salle F, Churg A, Roggli V, et al. The 2015 World Health Organization Classification of Tumors of the Pleura: advances since the 2004 classification. J Thorac Oncol 2016;11:142154.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Henderson DW, Reid G, Kao SC, et al. Challenges and controversies in the diagnosis of malignant mesothelioma: part 2. Malignant mesothelioma subtypes, pleural synovial sarcoma, molecular and prognostic aspects of mesothelioma, BAP1, aquaporin-1 and microRNA. J Clin Pathol 2013;66:854861.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20.

    Carbone M, Adusumilli PS, Alexander HR Jr, et al. Mesothelioma: scientific clues for prevention, diagnosis, and therapy. CA Cancer J Clin 2019;69:402429.

  • 21.

    Kusamura S, Kepenekian V, Villeneuve L, et al. Peritoneal mesothelioma: PSOGI/EURACAN clinical practice guidelines for diagnosis, treatment and follow-up. Eur J Surg Oncol 2021;47:3659.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22.

    Boffetta P. Epidemiology of peritoneal mesothelioma: a review. Ann Oncol 2007;18:985990.

  • 23.

    Consonni D, Calvi C, De Matteis S, et al. Peritoneal mesothelioma and asbestos exposure: a population-based case-control study in Lombardy, Italy. Occup Environ Med 2019;76:545553.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24.

    Kim J, Bhagwandin S, Labow DM. Malignant peritoneal mesothelioma: a review. Ann Transl Med 2017;5:236.

  • 25.

    Alpert N, van Gerwen M, Taioli E. Epidemiology of mesothelioma in the 21st century in Europe and the United States, 40 years after restricted/banned asbestos use. Transl Lung Cancer Res 2020;9(Suppl 1):S2838.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Delgermaa V, Takahashi K, Park EK, et al. Global mesothelioma deaths reported to the World Health Organization between 1994 and 2008. Bull World Health Organ 2011;89:716724C.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27.

    Park EK, Takahashi K, Hoshuyama T, et al. Global magnitude of reported and unreported mesothelioma. Environ Health Perspect 2011;119:514518.

  • 28.

    Bang KM, Mazurek JM, Storey E, et al. Malignant mesothelioma mortality—United States, 1999–2005. MMWR Morb Mortal Wkly Rep 2009;58:393396.

  • 29.

    Dagogo-Jack I, Madison RW, Lennerz JK, et al. Molecular characterization of mesothelioma: impact of histologic type and site of origin on molecular landscape. JCO Precis Oncol 2022;6:e2100422.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 30.

    Borczuk AC, Pei J, Taub RN, et al. Genome-wide analysis of abdominal and pleural malignant mesothelioma with DNA arrays reveals both common and distinct regions of copy number alteration. Cancer Biol Ther 2016;17:328335.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 31.

    Alakus H, Yost SE, Woo B, et al. BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma. J Transl Med 2015;13:122.

  • 32.

    Hung YP, Dong F, Watkins JC, et al. Identification of ALK rearrangements in malignant peritoneal mesothelioma. JAMA Oncol 2018;4:235238.

  • 33.

    Hung YP, Dong F, Torre M, et al. Molecular characterization of diffuse malignant peritoneal mesothelioma. Mod Pathol 2020;33:22692279.

  • 34.

    Leblay N, Leprêtre F, Le Stang N, et al. BAP1 is altered by copy number loss, mutation, and/or loss of protein expression in more than 70% of malignant peritoneal mesotheliomas. J Thorac Oncol 2017;12:724733.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 35.

    Desmeules P, Joubert P, Zhang L, et al. A subset of malignant mesotheliomas in young adults are associated with recurrent EWSR1/FUS-ATF1 fusions. Am J Surg Pathol 2017;41:980988.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 36.

    Dermawan JK, Torrence D, Lee CH, et al. EWSR1::YY1 fusion positive peritoneal epithelioid mesothelioma harbors mesothelioma epigenetic signature: Report of 3 cases in support of an emerging entity. Genes Chromosomes Cancer 2022;61:592602.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 37.

    Gerthofer V, Scheiter A, Lüke F, et al. STRN-ALK fusion in a case of malignant peritoneal mesothelioma: mixed response to crizotinib, mode of resistance, and brigatinib sequential therapy. JCO Precis Oncol 2021;5:PO.21.00184.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 38.

    García-Fadrique A, Mehta A, Mohamed F, et al. Clinical presentation, diagnosis, classification and management of peritoneal mesothelioma: a review. J Gastrointest Oncol 2017;8:915924.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 39.

    Sauter JL, Dacic S, Galateau-Salle F, et al. The 2021 WHO Classification of Tumors of the Pleura: advances since the 2015 classification. J Thorac Oncol 2022;17:608622.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 40.

    Hiltbrunner S, Fleischmann Z, Sokol ES, et al. Genomic landscape of pleural and peritoneal mesothelioma tumours. Br J Cancer 2022;127:19972005.

  • 41.

    Carlson B, Harmath C, Turaga K, et al. The role of imaging in diagnosis and management of malignant peritoneal mesothelioma: a systematic review. Abdom Radiol (NY) 2022;47:17251740.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 42.

    Yan TD, Haveric N, Carmignani CP, et al. Abdominal computed tomography scans in the selection of patients with malignant peritoneal mesothelioma for comprehensive treatment with cytoreductive surgery and perioperative intraperitoneal chemotherapy. Cancer 2005;103:839849.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 43.

    Pickhardt PJ, Perez AA, Elmohr MM, et al. CT imaging review of uncommon peritoneal-based neoplasms: beyond carcinomatosis. Br J Radiol 2021;94:20201288.

  • 44.

    Shrestha R, Nabavi N, Volik S, et al. Well-differentiated papillary mesothelioma of the peritoneum is genetically distinct from malignant mesothelioma. Cancers (Basel) 2020;12:1568.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 45.

    Churg A, Allen T, Borczuk AC, et al. Well-differentiated papillary mesothelioma with invasive foci. Am J Surg Pathol 2014;38:990998.

  • 46.

    Malpica A, Sant’Ambrogio S, Deavers MT, et al. Well-differentiated papillary mesothelioma of the female peritoneum: a clinicopathologic study of 26 cases. Am J Surg Pathol 2012;36:117127.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 47.

    Noiret B, Renaud F, Piessen G, et al. Multicystic peritoneal mesothelioma: a systematic review of the literature. Pleura Peritoneum 2019;4:20190024.

  • 48.

    Baratti D, Vaira M, Kusamura S, et al. Multicystic peritoneal mesothelioma: outcomes and patho-biological features in a multi-institutional series treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). Eur J Surg Oncol 2010;36:10471053.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 49.

    Baratti D, Kusamura S, Nonaka D, et al. Multicystic and well- differentiated papillary peritoneal mesothelioma treated by surgical cytoreduction and hyperthermic intra-peritoneal chemotherapy (HIPEC). Ann Surg Oncol 2007;14:27902797.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 50.

    Chapel DB, Schulte JJ, Husain AN, et al. Application of immunohistochemistry in diagnosis and management of malignant mesothelioma. Transl Lung Cancer Res 2020;9(Suppl 1):S327.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 51.

    Allen TC, Cagle PT, Churg AM, et al. Localized malignant mesothelioma. Am J Surg Pathol 2005;29:866873.

  • 52.

    Marchevsky AM, Khoor A, Walts AE, et al. Localized malignant mesothelioma, an unusual and poorly characterized neoplasm of serosal origin: best current evidence from the literature and the International Mesothelioma Panel. Mod Pathol 2020;33:281296.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 53.

    Jeppesen TD, Højsgaard A, Kjær D, et al. Localized malignant mesothelioma in the stomach and mediastinum. Interact Cardiovasc Thorac Surg 2022;34:485487.

  • 54.

    Liu S, Staats P, Lee M, et al. Diffuse mesothelioma of the peritoneum: correlation between histological and clinical parameters and survival in 73 patients. Pathology 2014;46:604609.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 55.

    Rizzuto I, Power T, Oehler MK. Diffuse peritoneal malignant mesothelioma presenting with abnormal uterine bleeding: case report. Case Rep Oncol 2022;15:251256.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 56.

    Lin LC, Kuan WY, Shiu BH, et al. Primary malignant peritoneal mesothelioma mimicking tuberculous peritonitis: a case report. World J Clin Cases 2022;10:31563163.

  • 57.

    WHO Classification of Tumours Editorial Board. WHO Classification of Tumours: Thoracic Tumours. 5th ed. International Agency for Research on Cancer; 2021.

  • 58.

    Schneider F, Roden AC, Dacic S, et al. Protocol for the examination of specimens from patients with malignant pleural mesothelioma: version 4.1.0.0. Accessed February 1, 2023. Available at: https://documents.cap.org/protocols/PleuraPericard_4.1.0.0.REL_CAPCP.pdf

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 59.

    Malpica A, Euscher ED, Marques-Piubelli ML, et al. Malignant mesothelioma of the peritoneum in women: a clinicopathologic study of 164 cases. Am J Surg Pathol 2021;45:4558.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 60.

    Kindler HL, Ismaila N, Armato SG III, et al. Treatment of malignant pleural mesothelioma: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol 2018;36:13431373.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 61.

    Chapel DB, Churg A, Santoni-Rugiu E, et al. Molecular pathways and diagnosis in malignant mesothelioma: a review of the 14th International Conference of the International Mesothelioma Interest Group. Lung Cancer 2019;127:6975.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 62.

    Henderson DW, Reid G, Kao SC, et al. Challenges and controversies in the diagnosis of mesothelioma: part 1. Cytology-only diagnosis, biopsies, immunohistochemistry, discrimination between mesothelioma and reactive mesothelial hyperplasia, and biomarkers. J Clin Pathol 2013;66:847853.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 63.

    Husain AN, Colby T, Ordonez N, et al. Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med 2013;137:647667.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 64.

    Husain AN, Colby TV, Ordóñez NG, et al. Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med 2009;133:13171331.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 65.

    Chapel DB, Husain AN, Krausz T, et al. PAX8 expression in a subset of malignant peritoneal mesotheliomas and benign mesothelium has diagnostic implications in the differential diagnosis of ovarian serous carcinoma. Am J Surg Pathol 2017;41:16751682.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 66.

    Offin M, Yang SR, Egger J, et al. Molecular characterization of peritoneal mesotheliomas. J Thorac Oncol 2022;17:455460.

  • 67.

    Churg A, Naso JR. The separation of benign and malignant mesothelial proliferations: new markers and how to use them. Am J Surg Pathol 2020;44:e100112.

  • 68.

    Singhi AD, Krasinskas AM, Choudry HA, et al. The prognostic significance of BAP1, NF2, and CDKN2A in malignant peritoneal mesothelioma. Mod Pathol 2016;29:1424.

  • 69.

    Tandon RT, Jimenez-Cortez Y, Taub R, et al. Immunohistochemistry in peritoneal mesothelioma: a single-center experience of 244 cases. Arch Pathol Lab Med 2018;142:236242.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 70.

    Kawai T, Tominaga S, Hiroi S, et al. Peritoneal malignant mesothelioma (PMM), and primary peritoneal serous carcinoma (PPSC) and reactive mesothelial hyperplasia (RMH) of the peritoneum. Immunohistochemical and fluorescence in situ hybridisation (FISH) analyses. J Clin Pathol 2016;69:706712.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 71.

    Andrici J, Jung J, Sheen A, et al. Loss of BAP1 expression is very rare in peritoneal and gynecologic serous adenocarcinomas and can be useful in the differential diagnosis with abdominal mesothelioma. Hum Pathol 2016;51:915.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 72.

    Schulte JJ, Husain AN. Update on the pathologic diagnosis of malignant mesothelioma. Transl Lung Cancer Res 2020;9:917923.

  • 73.

    Krasinskas AM, Bartlett DL, Cieply K, et al. CDKN2A and MTAP deletions in peritoneal mesotheliomas are correlated with loss of p16 protein expression and poor survival. Mod Pathol 2010;23:531538.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 74.

    Schuitevoerder D, Izquierdo FJ, Plana A, et al. The Chicago Consensus on peritoneal surface malignancies: management of peritoneal mesothelioma. Cancer 2020;126:25472552.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 75.

    Feldman AL, Libutti SK, Pingpank JF, et al. Analysis of factors associated with outcome in patients with malignant peritoneal mesothelioma undergoing surgical debulking and intraperitoneal chemotherapy. J Clin Oncol 2003;21:45604567.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 76.

    Yan TD, Deraco M, Baratti D, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: multi-institutional experience. J Clin Oncol 2009;27:62376242.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 77.

    Baratti D, Kusamura S, Cabras AD, et al. Diffuse malignant peritoneal mesothelioma: long-term survival with complete cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC). Eur J Cancer 2013;49:31403148.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 78.

    Votanopoulos KI, Sugarbaker P, Deraco M, et al. Is cytoreductive surgery with hyperthermic intraperitoneal chemotherapy justified for biphasic variants of peritoneal mesothelioma? Outcomes from the Peritoneal Surface Oncology Group International Registry. Ann Surg Oncol 2018;25:667673.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 79.

    Kaufman AJ, Flores RM. Surgical treatment of malignant pleural mesothelioma. Curr Treat Options Oncol 2011;12:201216.

  • 80.

    Sugarbaker DJ, Flores RM, Jaklitsch MT, et al. Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: results in 183 patients. J Thorac Cardiovasc Surg 1999;117:5463; discussion 63–65.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 81.

    Yan TD, Deraco M, Elias D, et al. A novel tumor-node-metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi-institutional database. Cancer 2011;117:18551863.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 82.

    Kusamura S, Baratti D, Younan R, et al. Impact of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy on systemic toxicity. Ann Surg Oncol 2007;14:25502558.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 83.

    Shetty SJ, Bathla L, Govindarajan V, et al. Comparison of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with mitomycin or carboplatin for diffuse malignant peritoneal mesothelioma. Am Surg 2014;80:348352.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 84.

    Kepenekian V, Elias D, Passot G, et al. Diffuse malignant peritoneal mesothelioma: evaluation of systemic chemotherapy with comprehensive treatment through the RENAPE Database: multi-institutional retrospective study. Eur J Cancer 2016;65:6979.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 85.

    Raghav K, Liu S, Overman MJ, et al. Efficacy, safety, and biomarker analysis of combined PD-L1 (atezolizumab) and VEGF (bevacizumab) blockade in advanced malignant peritoneal mesothelioma. Cancer Discov 2021;11:27382747.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 86.

    Jänne PA, Wozniak AJ, Belani CP, et al. Open-label study of pemetrexed alone or in combination with cisplatin for the treatment of patients with peritoneal mesothelioma: outcomes of an expanded access program. Clin Lung Cancer 2005;7:4046.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 87.

    Kitadai R, Shimoi T, Sudo K, et al. Efficacy of second-line treatment and prognostic factors in patients with advanced malignant peritoneal mesothelioma: a retrospective study. BMC Cancer 2021;21:294.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 88.

    Fennell DA, Ewings S, Ottensmeier C, et al. Nivolumab versus placebo in patients with relapsed malignant mesothelioma (CONFIRM): a multicentre, double-blind, randomised, phase 3 trial. Lancet Oncol 2021;22:15301540.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 89.

    Nagata Y, Sawada R, Takashima A, et al. Efficacy and safety of pemetrexed plus cisplatin as first-line chemotherapy in advanced malignant peritoneal mesothelioma. Jpn J Clin Oncol 2019;49:10041008.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 90.

    Kim JS, Lim SY, Hwang J, et al. A case report of primary pericardial malignant mesothelioma treated with pemetrexed and cisplatin. J Korean Med Sci 2017;32:18791884.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 91.

    Recabal P, Rosenzweig B, Bazzi WM, et al. Malignant mesothelioma of the tunica vaginalis testis: outcomes following surgical management beyond radical orchiectomy. Urology 2017;107:166170.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 92.

    Santoro A, O’Brien ME, Stahel RA, et al. Pemetrexed plus cisplatin or pemetrexed plus carboplatin for chemonaïve patients with malignant pleural mesothelioma: results of the International Expanded Access Program. J Thorac Oncol 2008;3:756763.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 93.

    Jänne PA, Wozniak AJ, Belani CP, et al. Pemetrexed alone or in combination with cisplatin in previously treated malignant pleural mesothelioma: outcomes from a phase IIIB expanded access program. J Thorac Oncol 2006;1:506512.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 94.

    Obasaju CK, Ye Z, Wozniak AJ, et al. Single-arm, open label study of pemetrexed plus cisplatin in chemotherapy naïve patients with malignant pleural mesothelioma: outcomes of an expanded access program. Lung Cancer 2007;55:187194.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 95.

    Fujimoto E, Kijima T, Kuribayashi K, et al. First-line chemotherapy with pemetrexed plus cisplatin for malignant peritoneal mesothelioma. Expert Rev Anticancer Ther 2017;17:865872.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 96.

    Kim ST, Park JY, Lee J, et al. The efficacy of the frontline platinum-based combination chemotherapy in malignant peritoneal mesothelioma. Jpn J Clin Oncol 2010;40:10311036.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 97.

    Tanida S, Kataoka H, Kubota E, et al. Combination chemotherapy with cisplatin and gemcitabine in malignant peritoneal mesothelioma. Int J Clin Oncol 2009;14:266269.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 98.

    Kobayashi S, Waragai T, Sano H, et al. Malignant peritoneal mesothelioma in a child: chemotherapy with gemcitabine and platinum was effective for the disease unresponsive to other treatments. Anticancer Drugs 2014;25:11021105.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 99.

    Simon GR, Verschraegen CF, Jänne PA, et al. Pemetrexed plus gemcitabine as first-line chemotherapy for patients with peritoneal mesothelioma: final report of a phase II trial. J Clin Oncol 2008;26:35673572.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 100.

    Raghav K, Liu S, Overman M, et al. Clinical efficacy of immune checkpoint inhibitors in patients with advanced malignant peritoneal mesothelioma. JAMA Netw Open 2021;4:e2119934.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 101.

    Miyagawa C, Takaya H, Sakai K, et al. A novel malignant peritoneal mesothelioma with STRN exon 2 and ALK exon 20: a case report and literature review. Oncologist 2021;26:356361.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 102.

    Mian I, Abdullaev Z, Morrow B, et al. Anaplastic lymphoma kinase gene rearrangement in children and young adults with mesothelioma. J Thorac Oncol 2020;15:457461.

  • 103.

    Argani P, Lian DWQ, Agaimy A, et al. Pediatric mesothelioma With ALK fusions: a molecular and pathologic study of 5 cases. Am J Surg Pathol 2021;45:653661.

  • 104.

    Rüschoff JH, Gradhand E, Kahraman A, et al. STRN-ALK rearranged malignant peritoneal mesothelioma with dramatic response following ceritinib treatment. JCO Precis Oncol 2019;3:PO.19.00048.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 105.

    Murumägi A, Ungureanu D, Arjama M, et al. STRN-ALK rearranged pediatric malignant peritoneal mesothelioma—functional testing of 527 cancer drugs in patient-derived cancer cells. Transl Oncol 2021;14:101027.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 106.

    Zalcman G, Mazieres J, Margery J, et al. Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial. Lancet 2016;387:14051414.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 107.

    Baas P, Scherpereel A, Nowak AK, et al. First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial. Lancet 2021;397:375386.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 108.

    Nowak AK, Byrne MJ, Williamson R, et al. A multicentre phase II study of cisplatin and gemcitabine for malignant mesothelioma. Br J Cancer 2002;87:491496.

  • 109.

    van Haarst JM, Baas P, Manegold Ch, et al. Multicentre phase II study of gemcitabine and cisplatin in malignant pleural mesothelioma. Br J Cancer 2002;86:342345.

  • 110.

    Taylor P, Castagneto B, Dark G, et al. Single-agent pemetrexed for chemonaïve and pretreated patients with malignant pleural mesothelioma: results of an International Expanded Access Program. J Thorac Oncol 2008;3:764771.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 111.

    Muers MF, Stephens RJ, Fisher P, et al. Active symptom control with or without chemotherapy in the treatment of patients with malignant pleural mesothelioma (MS01): a multicentre randomised trial. Lancet 2008;371:16851694.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 112.

    Jassem J, Ramlau R, Santoro A, et al. Phase III trial of pemetrexed plus best supportive care compared with best supportive care in previously treated patients with advanced malignant pleural mesothelioma. J Clin Oncol 2008;26:16981704.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 113.

    Scherpereel A, Mazieres J, Greillier L, et al. Nivolumab or nivolumab plus ipilimumab in patients with relapsed malignant pleural mesothelioma (IFCT-1501 MAPS2): a multicentre, open-label, randomised, non-comparative, phase 2 trial. Lancet Oncol 2019;20:239253.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 114.

    Zucali PA, Simonelli M, Michetti G, et al. Second-line chemotherapy in malignant pleural mesothelioma: results of a retrospective multicenter survey. Lung Cancer 2012;75:360367.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 115.

    Bearz A, Talamini R, Rossoni G, et al. Re-challenge with pemetrexed in advanced mesothelioma: a multi-institutional experience. BMC Res Notes 2012;5:482.

  • 116.

    Gilani SN, Gridley R, Searle G, et al. Malignant peritoneal mesothelioma (MPM) who responded to rechallenge with cisplatin and pemetrexed with current literature review. BMJ Case Rep 2013;2013:bcr2012007786.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 117.

    Stebbing J, Powles T, McPherson K, et al. The efficacy and safety of weekly vinorelbine in relapsed malignant pleural mesothelioma. Lung Cancer 2009;63:9497.

  • 118.

    Zauderer MG, Kass SL, Woo K, et al. Vinorelbine and gemcitabine as second- or third-line therapy for malignant pleural mesothelioma. Lung Cancer 2014;84:271274.

  • 119.

    Manegold C, Symanowski J, Gatzemeier U, et al. Second-line (post-study) chemotherapy received by patients treated in the phase III trial of pemetrexed plus cisplatin versus cisplatin alone in malignant pleural mesothelioma. Ann Oncol 2005;16:923927.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 120.

    van Meerbeeck JP, Baas P, Debruyne C, et al. A phase II study of gemcitabine in patients with malignant pleural mesothelioma. Cancer 1999;85:25772582.

  • 121.

    Mazurek JM, Syamlal G, Wood JM, et al. Malignant mesothelioma mortality - United States, 1999–2015. MMWR Morb Mortal Wkly Rep 2017;66:214218.

  • 122.

    Meyerhoff RR, Yang CF, Speicher PJ, et al. Impact of mesothelioma histologic subtype on outcomes in the Surveillance, Epidemiology, and End Results database. J Surg Res 2015;196:2332.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 123.

    Musk AW, Olsen N, Alfonso H, et al. Predicting survival in malignant mesothelioma. Eur Respir J 2011;38:14201424.

  • 124.

    Linton A, Pavlakis N, O’Connell R, et al. Factors associated with survival in a large series of patients with malignant pleural mesothelioma in New South Wales. Br J Cancer 2014;111:18601869.

    • PubMed
    • Search Google Scholar
    • Export Citation

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