Multiple Myeloma, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology

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Shaji K. Kumar Mayo Clinic Comprehensive Cancer Center

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Natalie S. Callander University of Wisconsin Carbone Cancer Center

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Kehinde Adekola Robert H. Lurie Comprehensive Cancer Center of Northwestern University

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Larry D. Anderson Jr UT Southwestern Simmons Comprehensive Cancer Center

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Muhamed Baljevic Vanderbilt-Ingram Cancer Center

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Rachid Baz Moffitt Cancer Center

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Erica Campagnaro University of Michigan Rogel Cancer Center

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Jorge J. Castillo Dana-Farber/Brigham and Women’s Cancer Center | Mass General Cancer Center

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Caitlin Costello UC San Diego Moores Cancer Center

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Christopher D’Angelo Fred & Pamela Buffett Cancer Center

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Srinivas Devarakonda The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute

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Noura Elsedawy St. Jude Children’s Research Hospital/The University of Tennessee Health Science Center

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Alfred Garfall Abramson Cancer Center at the University of Pennsylvania

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Kelly Godby O’Neal Comprehensive Cancer Center at UAB

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Jens Hillengass Roswell Park Comprehensive Cancer Center

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Leona Holmberg Fred Hutchinson Cancer Center

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Myo Htut City of Hope National Medical Center

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Carol Ann Huff The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

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Malin Hultcrantz Memorial Sloan Kettering Cancer Center

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Yubin Kang Duke Cancer Institute

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Sarah Larson UCLA Jonsson Comprehensive Cancer Center

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Hans C. Lee The University of Texas MD Anderson Cancer Center

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Michaela Liedtke Stanford Cancer Institute

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Thomas Martin UCSF Helen Diller Family Comprehensive Cancer Center

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James Omel Patient Advocate

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Timothy Robinson Yale Cancer Center/Smilow Cancer Hospital

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Aaron Rosenberg UC Davis Comprehensive Cancer Center

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Douglas Sborov Huntsman Cancer Institute at the University of Utah

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Mark A. Schroeder Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine

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Daniel Sherbenou University of Colorado Cancer Center

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Attaya Suvannasankha Indiana University Melvin and Bren Simon Comprehensive Cancer Center

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Jason Valent Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute

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Asya Nina Varshavsky-Yanovsky Fox Chase Cancer Center

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Rashmi Kumar National Comprehensive Cancer Network

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Jenna Snedeker National Comprehensive Cancer Network

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The treatment of relapsed/refractory multiple myeloma (MM) has evolved to include several new options. These include new combinations with second generation proteasome inhibitors (PI); second generation immunomodulators, monoclonal antibodies, CAR T cells, bispecific antibodies, selinexor, venetoclax, and many others. Most patients with MM undergo several cycles of remissions and relapse, and therefore need multiple lines of combination therapies. Selecting treatment options for relapsed/refractory MM requires consideration of resistance status to specific classes, and patient-specific factors such as age and other comorbidities should be considered. The NCCN Guidelines for MM provide a framework on which to base decisions regarding workup, treatment, and follow-up of newly diagnosed and previously treated MM. This manuscript outlines the recommendations from NCCN Guidelines for MM specific to relapsed/refractory disease.

Individual Disclosures for the NCCN Multiple Myeloma Panel
Individual Disclosures for the NCCN Multiple Myeloma Panel

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