Prostate Cancer, Version 4.2023, NCCN Clinical Practice Guidelines in Oncology

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Edward M. Schaeffer Robert H. Lurie Comprehensive Cancer Center of Northwestern University

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Sandy Srinivas Stanford Cancer Institute

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Nabil Adra Indiana University Melvin and Bren Simon Comprehensive Cancer Center

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Yi An Yale Cancer Center/Smilow Cancer Hospital

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Daniel Barocas Vanderbilt-Ingram Cancer Center

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Rhonda Bitting Duke Cancer Institute

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Alan Bryce Mayo Clinic Comprehensive Cancer Center

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Brian Chapin The University of Texas MD Anderson Cancer Center

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Heather H. Cheng Fred Hutchinson Cancer Center

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Anthony Victor D’Amico Dana-Farber/Brigham and Women’s Cancer Center | Mass General Cancer Center

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Neil Desai UT Southwestern Simmons Comprehensive Cancer Center

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Tanya Dorff City of Hope National Cancer Center

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James A. Eastham Memorial Sloan Kettering Cancer Center

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Thomas A. Farrington Prostate Health Education Network (PHEN)

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Xin Gao Dana-Farber/Brigham and Women’s Cancer Center | Mass General Cancer Center

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Shilpa Gupta Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute

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Thomas Guzzo Abramson Cancer Center at The University of Pennsylvania

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Joseph E. Ippolito Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine

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Michael R. Kuettel Roswell Park Comprehensive Cancer Center

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Joshua M. Lang University of Wisconsin Carbone Cancer Center

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Tamara Lotan The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

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Rana R. McKay UC San Diego Moores Cancer Center

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Todd Morgan University of Michigan Rogel Cancer Center

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George Netto O’Neal Comprehensive Cancer Center at UAB

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Julio M. Pow-Sang Moffitt Cancer Center

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Robert Reiter UCLA Jonsson Comprehensive Cancer Center

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Mack Roach III UCSF Helen Diller Family Comprehensive Cancer Center

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Tyler Robin University of Colorado Cancer Center

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Stan Rosenfeld University of California San Francisco, Patient Services Committee Chair

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Ahmad Shabsigh The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute

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Jonathan Tward Huntsman Cancer Institute at the University of Utah

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Richard Valicenti UC Davis Comprehensive Cancer Center

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Dorothy A. Shead National Comprehensive Cancer Network

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Jenna Snedeker National Comprehensive Cancer Network

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Deborah A. Freedman-Cass National Comprehensive Cancer Network

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The NCCN Guidelines for Prostate Cancer provide a framework on which to base decisions regarding the workup of patients with prostate cancer, risk stratification and management of localized disease, post-treatment monitoring, and treatment of recurrence and advanced disease. The Guidelines sections included in this article focus on the management of metastatic castration-sensitive disease, nonmetastatic castration-resistant prostate cancer (CRPC), and metastatic CRPC (mCRPC). Androgen deprivation therapy (ADT) with treatment intensification is strongly recommended for patients with metastatic castration-sensitive prostate cancer. For patients with nonmetastatic CRPC, ADT is continued with or without the addition of certain secondary hormone therapies depending on prostate-specific antigen doubling time. In the mCRPC setting, ADT is continued with the sequential addition of certain secondary hormone therapies, chemotherapies, immunotherapies, radiopharmaceuticals, and/or targeted therapies. The NCCN Prostate Cancer Panel emphasizes a shared decision-making approach in all disease settings based on patient preferences, prior treatment exposures, the presence or absence of visceral disease, symptoms, and potential side effects.

Individual Disclosures for the NCCN Prostate Cancer Panel
Individual Disclosures for the NCCN Prostate Cancer Panel

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