Systemic Light Chain Amyloidosis, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology

Authors:
Shaji K. Kumar Mayo Clinic Cancer Center

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Natalie S. Callander University of Wisconsin Carbone Cancer Center

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Kehinde Adekola Robert H. Lurie Comprehensive Cancer Center of Northwestern University

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Larry D. Anderson Jr. UT Southwestern Simmons Comprehensive Cancer Center

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Muhamed Baljevic Vanderbilt-Ingram Cancer Center

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Erica Campagnaro University of Michigan Rogel Cancer Center

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Jorge J. Castillo Dana-Farber/Brigham and Women’s Cancer Center | Massachusetts General Hospital Cancer Center

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Caitlin Costello UC San Diego Moores Cancer Center

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Christopher D’Angelo Fred & Pamela Buffett Cancer Center

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Srinivas Devarakonda The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute

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Noura Elsedawy St. Jude Children’s Research Hospital/The University of Tennessee Health Science Center

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Alfred Garfall Abramson Cancer Center at the University of Pennsylvania

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Kelly Godby O’Neal Comprehensive Cancer Center at UAB

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Jens Hillengass Roswell Park Comprehensive Cancer Center

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Leona Holmberg Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance

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Myo Htut City of Hope National Medical Center

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Carol Ann Huff The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

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Malin Hultcrantz Memorial Sloan Kettering Cancer Center

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Yubin Kang Duke Cancer Institute

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Sarah Larson UCLA Jonsson Comprehensive Cancer Center

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Hans C. Lee The University of Texas MD Anderson Cancer Center

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Michaela Liedtke Stanford Cancer Institute

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Thomas Martin UCSF Helen Diller Family Comprehensive Cancer Center

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James Omel Patient advocate

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Aaron Rosenberg UC Davis Comprehensive Cancer Center

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Douglas Sborov Huntsman Cancer Institute at the University of Utah

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Jason Valent Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute

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Ryan Berardi National Comprehensive Cancer Network

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Rashmi Kumar National Comprehensive Cancer Network

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Primary systemic light chain amyloidosis (SLCA) is characterized by production of light chains that get converted to amyloid fibrils with an affinity for visceral organs and causing organ dysfunction. The therapy for SLCA is directed to recovering the function of the affected organs by targeting the abnormal plasma cell clone and slowing deposition of amyloid fibrils. The NCCN Guidelines for SLCA provide recommendations for workup, diagnosis, and treatment of primary as well as previously treated SLCA.

Individual Disclosures for the NCCN Guidelines Panel for Systemic Light Chain Amyloidosis
Individual Disclosures for the NCCN Guidelines Panel for Systemic Light Chain Amyloidosis

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    Wechalekar AD, Cibeira MT, Gibbs SD, et al. Guidelines for non- transplant chemotherapy for treatment of systemic AL amyloidosis: EHA-ISA working group. Amyloid. Published online July 15, 2022. doi:10.1080/13506129.2022.2093635

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