Role of Radiation Therapy in Retroperitoneal Sarcoma

Authors:
Kilian E. Salerno Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; and

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 MD
and
Elizabeth H. Baldini Harvard Medical School, and
Sarcoma Center, Dana-Farber Cancer Institute/Brigham and Women’s Hospital, Boston, Massachusetts.

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Volume/Issue:
Volume 20: Issue 7
Online Publication Date:
Jul 2022
DOI:
https://doi.org/10.6004/jnccn.2022.7035
Restricted access

Retroperitoneal sarcoma comprises a small subset of all soft tissue sarcoma and includes various histopathologic subtypes, each with unique patterns of behavior and differential risks for local recurrence and hematogenous metastatic spread. The primary treatment modality is surgery, although even with complete macroscopic resection, recurrence is common. The rationale for the addition of radiotherapy to resection is to improve local control; however, the use of radiation therapy for retroperitoneal sarcoma is controversial, and existing data are suboptimal to guide management. Treatment decisions should be determined with multidisciplinary input and shared decision-making. When used in selected patients, radiation therapy should be delivered preoperatively; postoperative treatment is not recommended.

Submitted February 25, 2022; final revision received May 19, 2022; accepted for publication May 19, 2022.

Disclosures: Dr. Baldini has disclosed receiving royalties from UpToDate, Inc. Dr. Salerno has disclosed having no financial interests, arrangements, affiliations, or commercial interests with manufacturers of any products discussed in this article or their competitors.

Correspondence: Kilian E. Salerno, MD, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10 CCR, Room B2-3500, Bethesda, MD 20892. Email: kilian.salerno@nih.gov
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Copyright:
Copyright © 2022 by the National Comprehensive Cancer Network 2022
Page Numbers:
5
Article Category:
Review Article
Received:
25 Feb 2022
Accepted:
19 May 2022
Print Publication Date:
01 Jul 2022
Online Publication Date:
Jul 2022
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