NCCN Guidelines Updates: Management of Patients With HER2-Negative Breast Cancer

Presented by:
William J. Gradishar
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Volume/Issue:
Volume 20: Issue 5.5
Online Publication Date:
02 Jun 2022
DOI:
https://doi.org/10.6004/jnccn.2022.5016
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Treatment for metastatic HER2-negative breast cancer is becoming increasingly individualized as more of the tumor landscape is described and drugs are developed to target its pathways. Survival can be prolonged by CDK4/6 inhibitors in patients with hormone receptor–positive tumors and by immunotherapy in those with triple-negative disease. In patients with BRCA1/2 mutations, PARP inhibitors delay disease progression. Antibody–drug conjugates are expected to become critical components of the treatment landscape, and targeted drugs are proving to benefit small subsets of patients.

Disclosures: Dr. Gradishar has disclosed serving as a scientific advisor for AstraZeneca Pharmaceuticals LP, Daiichi-Sankyo Co., Eli Lilly and Company, ImmunoGen, Inc., MacroGenics, Puma Biotechnology, and Seattle Genetics, Inc.; and receiving honoraria from AstraZeneca Pharmaceuticals LP, Biotheranostics, Daiichi-Sankyo Co., ImmunoGen, Inc.

Correspondence: William J. Gradishar, MD, Robert H. Lurie Comprehensive Cancer Center at Northwestern University, 676 North St. Clair Street, Suite 850, Chicago, IL 60611. Email: w-gradishar@northwestern.edu
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Print ISSN:
1540-1405
Online ISSN:
1540-1413
Publisher:
National Comprehensive Cancer Network
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Copyright:
Copyright © 2022 by the National Comprehensive Cancer Network 2022
Page Numbers:
5
Article Category:
Research Article
Print Publication Date:
01 May 2022
Online Publication Date:
02 Jun 2022

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