For patients undergoing treatment for cancer-induced pain, the identification and evaluation of pharmacogenetic variability may improve outcomes. Metabolism of opioids and other analgesic agents is influenced by patient-specific variables and drug–drug interactions, which often pose clinical challenges. Consultation with a clinical pharmacist or pharmacogenetics specialist is recommended to aid in the interpretation and evaluation of pharmacogenetic test results. The current NCCN Guidelines for Adult Cancer Pain provide pharmacogenetic considerations and recommendations for the treatment and supportive care of this population.
Disclosures: Dr. Craig has disclosed receiving consulting fees from Purdue Pharma LP and Trevena.
Correspondence: David S. Craig, PharmD, Moffitt Cancer Center, Department of Pharmacy, 12902 Magnolia Drive, Tampa, FL 33612. Email: email@example.com
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