The Role of Tissue Biopsy in the Management of Immune Checkpoint Inhibitor Toxicity

Authors:
Leslie A. Fecher Division of Hematology/Oncology,

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,
Shrinivas Bishu Division of Gastroenterology, and

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,
Robert J. Fontana Division of Gastroenterology, and

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Salim S. Hayek Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan.

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Bryan J. Schneider Division of Hematology/Oncology,

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Volume/Issue:
Volume 20: Issue 4
Online Publication Date:
Apr 2022
DOI:
https://doi.org/10.6004/jnccn.2022.7011
Restricted access

Immune checkpoint inhibitors have revolutionized the treatment of cancer and are now omnipresent. However, immune-related adverse events can present with varying phenotypes and timing, which can pose diagnostic and therapeutic challenges for the treating oncologist as well as subspecialty consultants. Biopsies of affected organs may provide insight into biologic mechanisms as well as potentially guide management in certain circumstances.

Submitted December 20, 2021; accepted for publication February 23, 2022.

Disclosures: Dr. Fecher has disclosed participating in research for and serving as a principal investigator for Bristol-Myers Squibb, EMD Serono, Array, Pfizer, and Kartos; and serving as a consultant for Elsevier. The remaining authors have disclosed that they have no financial interests, arrangements, affiliations, or commercial interests with the manufacturers of any products discussed in this article or their competitors.

Correspondence: Bryan J. Schneider, MD, Division of Hematology/Oncology, University of Michigan, C411MIB, 1500 East Medical Center Drive, SPC 5848, Ann Arbor, MI 48109-5848. Email: bryansch@med.umich.edu
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Print ISSN:
1540-1405
Online ISSN:
1540-1413
Publisher:
National Comprehensive Cancer Network
Cover Journal of the National Comprehensive Cancer Network
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Copyright:
Copyright © 2022 by the National Comprehensive Cancer Network 2022
Page Numbers:
9
Article Category:
Research Article
Received:
20 Dec 2021
Accepted:
23 Feb 2022
Print Publication Date:
01 Apr 2022
Online Publication Date:
Apr 2022

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