Exceptional Response to Erdafitinib in FGFR2-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

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Camille F. NgSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, and

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John GlaspyJonsson Comprehensive Cancer Center, University of California, Los Angeles School of Medicine, Los Angeles, California.

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Veronica R. Placencio-HickokSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, and

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Shant ThomassianSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, and

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Jun GongSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, and

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Arsen OsipovSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, and

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Andrew E. HendifarSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, and

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Natalie MoshayediSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, and

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Despite advances in cancer therapeutics, pancreatic ductal adenocarcinoma (PDAC) remains among the deadliest malignancies, with a poor prognosis at time of diagnosis. Research in PDAC has suggested that adaptive signaling in the tumor microenvironment may promote tumor proliferation and survival. Several FGFR fusion genes—specifically FGFR2—are involved with the creation and progression of cancer. These mutations are found in a variety of cancer types. This report presents a unique case of a young patient with stage IV PDAC with a known FGFR2 fusion. This molecular alteration afforded a remarkable response to FGFR inhibitor therapy, erdafitinib, after the patient experienced disease progression on multiple chemotherapy regimens.

Submitted April 5, 2022; final revision received May 24, 2022; accepted for publication May 24, 2022.

Disclosures: The authors have disclosed that they have not received any financial consideration from any person or organization to support the preparation, analysis, results, or discussion of this article.

Correspondence: Natalie Moshayedi, BA, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048. Email: natalie.moshayedi@gmail.com
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