Acute Lymphoblastic Leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology

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  • 1 The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;
  • | 2 Moffitt Cancer Center;
  • | 3 Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;
  • | 4 City of Hope National Medical Center;
  • | 5 Huntsman Cancer Institute at the University of Utah;
  • | 6 University of Michigan Rogel Cancer Center;
  • | 7 Dana-Farber/Brigham and Women’s Cancer Center;
  • | 8 Robert H. Lurie Comprehensive Cancer Center of Northwestern University;
  • | 9 Massachusetts General Hospital Cancer Center;
  • | 10 Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;
  • | 11 The University of Texas MD Anderson Cancer Center;
  • | 12 Duke Cancer Institute;
  • | 13 Stanford Cancer Institute;
  • | 14 Mayo Clinic Cancer Center;
  • | 15 UCSF Helen Diller Family Comprehensive Cancer Center;
  • | 16 Abramson Cancer Center at the University of Pennsylvania;
  • | 17 Fred & Pamela Buffett Cancer Center;
  • | 18 Yale Cancer Center/Smilow Cancer Hospital;
  • | 19 University of Wisconsin Carbone Cancer Center;
  • | 20 UCLA Jonsson Comprehensive Cancer Center;
  • | 21 Vanderbilt-Ingram Cancer Center;
  • | 22 Memorial Sloan Kettering Cancer Center;
  • | 23 Roswell Park Comprehensive Cancer Center;
  • | 24 O'Neal Comprehensive Cancer Center at UAB;
  • | 25 St. Jude Children’s Research Hospital/The University of Tennessee Health Science Center;
  • | 26 Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;
  • | 27 UT Southwestern Simmons Comprehensive Cancer Center;
  • | 28 UC San Diego Moores Cancer Center; and
  • | 29 National Comprehensive Cancer Network.

The NCCN Guidelines for Acute Lymphoblastic Leukemia (ALL) focus on the classification of ALL subtypes based on immunophenotype and cytogenetic/molecular markers; risk assessment and stratification for risk-adapted therapy; treatment strategies for Philadelphia chromosome (Ph)-positive and Ph-negative ALL for both adolescent and young adult and adult patients; and supportive care considerations. Given the complexity of ALL treatment regimens and the required supportive care measures, the NCCN ALL Panel recommends that patients be treated at a specialized cancer center with expertise in the management of ALL This portion of the Guidelines focuses on the management of Ph-positive and Ph-negative ALL in adolescents and young adults, and management in relapsed settings.

Individual Disclosures for the NCCN Acute Lymphoblastic Leukemia Panel

T1

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