Wilms Tumor (Nephroblastoma), Version 2.2021, NCCN Clinical Practice Guidelines in Oncology

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  • 1 Abramson Cancer Center at the University of Pennsylvania;
  • | 2 St. Jude Children’s Research Hospital/The University of Tennessee Health Science Center;
  • | 3 City of Hope National Medical Center;
  • | 4 University of Wisconsin Carbone Cancer Center;
  • | 5 Moffitt Cancer Center;
  • | 6 Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;
  • | 7 Stanford Cancer Institute;
  • | 8 University of Michigan Rogel Cancer Center;
  • | 9 Fred & Pamela Buffett Cancer Center;
  • | 10 Vanderbilt-Ingram Cancer Center;
  • | 11 UC San Diego Moores Cancer Center;
  • | 12 UCLA Jonsson Comprehensive Cancer Center;
  • | 13 Dana-Farber/Brigham and Women’s Cancer Center;
  • | 14 Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;
  • | 15 The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute;
  • | 16 The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;
  • | 17 Roswell Park Comprehensive Cancer Center;
  • | 18 Duke Cancer Institute;
  • | 19 Mayo Clinic Cancer Center;
  • | 20 Memorial Sloan Kettering Cancer Center;
  • | 21 Robert H. Lurie Comprehensive Cancer Center of Northwestern University;
  • | 22 UT Southwestern Simmons Comprehensive Cancer Center;
  • | 23 UCSF Helen Diller Family Comprehensive Cancer Center; and
  • | 24 National Comprehensive Cancer Network.
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The NCCN Guidelines for Wilms Tumor focus on the screening, diagnosis, staging, treatment, and management of Wilms tumor (WT, also known as nephroblastoma). WT is the most common primary renal tumor in children. Five-year survival is more than 90% for children with all stages of favorable histology WT who receive appropriate treatment. All patients with WT should be managed by a multidisciplinary team with experience in managing renal tumors; consulting a pediatric oncologist is strongly encouraged. Treatment of WT includes surgery, neoadjuvant or adjuvant chemotherapy, and radiation therapy (RT) if needed. Careful use of available therapies is necessary to maximize cure and minimize long-term toxicities. This article discusses the NCCN Guidelines recommendations for favorable histology WT.

Individual Disclosures for the NCCN Wilms Tumor (Nephroblastoma) Panel

T1

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