Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology

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Manisha H. ShahThe Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

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Whitney S. GoldnerFred & Pamela Buffett Cancer Center;

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Al B. Benson IIIRobert H. Lurie Comprehensive Cancer Center of Northwestern University;

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Emily BergslandUCSF Helen Diller Family Comprehensive Cancer Center;

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Lawrence S. BlaszkowskyMassachusetts General Hospital Cancer Center;

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Pamela BrockThe Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

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Jennifer ChanDana-Farber/Brigham and Women’s Cancer Center;

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Satya DasVanderbilt-Ingram Cancer Center;

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Paxton V. DicksonSt. Jude Children's Research Hospital/The University of Tennessee Health Science Center;

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Paul FantaUC San Diego Moores Cancer Center;

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Thomas GiordanoUniversity of Michigan Rogel Cancer Center;

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Thorvardur R. HalfdanarsonMayo Clinic Cancer Center;

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Daniel HalperinThe University of Texas MD Anderson Cancer Center;

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Jin HeThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

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Anthony HeaneyUCLA Jonsson Comprehensive Cancer Center;

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Martin J. HeslinO'Neal Comprehensive Cancer Center at UAB;

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Fouad KandeelCity of Hope National Medical Center;

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Arash KardanCase Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

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Sajid A. KhanYale Cancer Center/Smilow Cancer Hospital;

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Boris W. Kuvshinoff IIRoswell Park Comprehensive Cancer Center;

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Christopher LieuUniversity of Colorado Cancer Center;

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Kimberly MillerFred & Pamela Buffett Cancer Center;

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Venu G. PillarisettyFred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

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Diane ReidyMemorial Sloan Kettering Cancer Center;

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Sarimar Agosto SalgadoUT Southwestern Simmons Comprehensive Cancer Center;

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Shagufta ShaheenStanford Cancer Institute;

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Heloisa P. SoaresHuntsman Cancer Institute at the University of Utah;

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Michael C. SoulenAbramson Cancer Center at the University of Pennsylvania;

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Jonathan R. StrosbergMoffitt Cancer Center;

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Craig R. SussmanVanderbilt-Ingram Cancer Center;

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Nikolaos A. TrikalinosSiteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

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Nataliya A. UbohaUniversity of Wisconsin Carbone Cancer Center;

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Namrata VijayvergiaFox Chase Cancer Center;

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Terence WongDuke Cancer Institute; and

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Beth LynnNational Comprehensive Cancer Network;

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Cindy HochstetlerNational Comprehensive Cancer Network;

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The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Neuroendocrine and Adrenal Gland Tumors focus on the diagnosis, treatment, and management of patients with neuroendocrine tumors (NETs), adrenal tumors, pheochromocytomas, paragangliomas, and multiple endocrine neoplasia. NETs are generally subclassified by site of origin, stage, and histologic characteristics. Appropriate diagnosis and treatment of NETs often involves collaboration between specialists in multiple disciplines, using specific biochemical, radiologic, and surgical methods. Specialists include pathologists, endocrinologists, radiologists (including nuclear medicine specialists), and medical, radiation, and surgical oncologists. These guidelines discuss the diagnosis and management of both sporadic and hereditary neuroendocrine and adrenal tumors and are intended to assist with clinical decision-making. This article is focused on the 2021 NCCN Guidelines principles of genetic risk assessment and counseling and recommendations for well-differentiated grade 3 NETs, poorly differentiated neuroendocrine carcinomas, adrenal tumors, pheochromocytomas, and paragangliomas.

Individual Disclosures for the NCCN Neuroendocrine and Adrenal Tumors Panel

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