Hepatobiliary Cancers, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology

Authors:
Al B. Benson Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

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Michael I. D’Angelica Memorial Sloan Kettering Cancer Center;

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Daniel E. Abbott University of Wisconsin Carbone Cancer Center;

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Daniel A. Anaya Moffitt Cancer Center;

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Robert Anders The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

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Chandrakanth Are Fred & Pamela Buffett Cancer Center;

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Melinda Bachini The Cholangiocarcinoma Foundation;

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Mitesh Borad Mayo Clinic Cancer Center;

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Daniel Brown Vanderbilt-Ingram Cancer Center;

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Adam Burgoyne UC San Diego Moores Cancer Center;

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Prabhleen Chahal Case Comprehensive Cancer Center, University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

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Daniel T. Chang Stanford Cancer Institute;

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Jordan Cloyd The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

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Anne M. Covey Memorial Sloan Kettering Cancer Center;

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Evan S. Glazer St. Jude Children's Research HospitalThe University of Tennessee Health Science Center;

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Lipika Goyal Massachusetts General Hospital Cancer Center;

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William G. Hawkins Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

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Renuka Iyer Roswell Park Comprehensive Cancer Center;

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Rojymon Jacob O'Neal Comprehensive Cancer Center at UAB;

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R. Kate Kelley UCSF Helen Diller Family Comprehensive Cancer Center;

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Robin Kim Huntsman Cancer Institute at the University of Utah;

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Matthew Levine Abramson Cancer Center at the University of Pennsylvania;

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Manisha Palta Duke Cancer Institute;

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James O. Park Fred Hutchinson Cancer Research CenterSeattle Cancer Care Alliance;

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Steven Raman UCLA Jonsson Comprehensive Cancer Center;

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Sanjay Reddy Fox Chase Cancer Center;

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Vaibhav Sahai University of Michigan Rogel Cancer Center;

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Tracey Schefter University of Colorado Cancer Center;

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Gagandeep Singh City of Hope National Medical Center;

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Stacey Stein Yale Cancer Center/Smilow Cancer Hospital;

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Jean-Nicolas Vauthey The University of Texas MD Anderson Cancer Center;

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Alan P. Venook UCSF Helen Diller Family Comprehensive Cancer Center;

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Adam Yopp UT Southwestern Simmons Comprehensive Cancer Center; and

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Nicole R. McMillian National Comprehensive Cancer Network.

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Cindy Hochstetler National Comprehensive Cancer Network.

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Susan D. Darlow National Comprehensive Cancer Network.

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Volume/Issue:
Volume 19: Issue 5
Online Publication Date:
01 May 2021
DOI:
https://doi.org/10.6004/jnccn.2021.0022
Restricted access

The NCCN Guidelines for Hepatobiliary Cancers focus on the screening, diagnosis, staging, treatment, and management of hepatocellular carcinoma (HCC), gallbladder cancer, and cancer of the bile ducts (intrahepatic and extrahepatic cholangiocarcinoma). Due to the multiple modalities that can be used to treat the disease and the complications that can arise from comorbid liver dysfunction, a multidisciplinary evaluation is essential for determining an optimal treatment strategy. A multidisciplinary team should include hepatologists, diagnostic radiologists, interventional radiologists, surgeons, medical oncologists, and pathologists with hepatobiliary cancer expertise. In addition to surgery, transplant, and intra-arterial therapies, there have been great advances in the systemic treatment of HCC. Until recently, sorafenib was the only systemic therapy option for patients with advanced HCC. In 2020, the combination of atezolizumab and bevacizumab became the first regimen to show superior survival to sorafenib, gaining it FDA approval as a new frontline standard regimen for unresectable or metastatic HCC. This article discusses the NCCN Guidelines recommendations for HCC.

Individual Disclosures for the NCCN Hepatobiliary Cancers Panel
T1

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Print ISSN:
1540-1405
Online ISSN:
1540-1413
Publisher:
National Comprehensive Cancer Network
Cover Journal of the National Comprehensive Cancer Network
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