The advent of immune checkpoint inhibitors (ICIs) has changed the game in cancer immunotherapy, specifically in the treatment of urothelial bladder cancer. Several clinical trials combining chemotherapy with ICIs have resulted in approvals from the FDA and subsequent revisions within the NCCN Guidelines. The current NCCN Guidelines for Bladder Cancer reflect the most up-to-date, evidence-based data relating to the evaluation and management of urothelial bladder cancer. ICIs have been incorporated into the guidelines as maintenance therapy in response to chemotherapy, sequencing after disease progression from frontline chemotherapy, and for the treatment of non–muscle-invasive bladder cancer.
Disclosures: Dr. Siefker-Radtke has disclosed serving as a scientific advisor for AstraZeneca Pharmaceuticals LP, Bavarian Nordic, Bristol Myers Squibb Company, Genentech, Inc., Immunomedics, Inc., Janssen Pharmaceutica Products, LP, Merck & Co., Inc., Mirati Therapeutics, Inc., Nektar Therapeutics, Seattle Genetics, Inc., and Taiho Pharmaceuticals Co., Ltd.