Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology

Authors:
Deborah K. Armstrong The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

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Ronald D. Alvarez Vanderbilt-Ingram Cancer Center;

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Jamie N. Bakkum-Gamez Mayo Clinic Cancer Center;

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Lisa Barroilhet University of Wisconsin Carbone Cancer Center;

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Kian Behbakht University of Colorado Cancer Center;

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Andrew Berchuck Duke Cancer Institute;

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Lee-may Chen UCSF Helen Diller Family Comprehensive Cancer Center;

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Mihaela Cristea City of Hope National Medical Center;

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Maria DeRosa Patient Advocate;

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Eric L. Eisenhauer Massachusetts General Hospital Cancer Center;

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David M. Gershenson The University of Texas MD Anderson Cancer Center;

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Heidi J. Gray Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

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Rachel Grisham Memorial Sloan Kettering Cancer Center;

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Ardeshir Hakam Moffitt Cancer Center;

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Angela Jain Fox Chase Cancer Center;

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Amer Karam Stanford Cancer Institute;

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Gottfried E. Konecny UCLA Jonsson Comprehensive Cancer Center;

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Charles A. Leath III O'Neal Comprehensive Cancer Center at UAB;

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Joyce Liu Dana-Farber/Brigham and Women’s Cancer Center;

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Haider Mahdi Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

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Lainie Martin Abramson Cancer Center at the University of Pennsylvania;

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Daniela Matei Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

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Michael McHale UC San Diego Moores Cancer Center;

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Karen McLean University of Michigan Rogel Cancer Center;

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David S. Miller UT Southwestern Simmons Comprehensive Cancer Center;

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David M. O’Malley The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

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Sanja Percac-Lima Massachusetts General Hospital Cancer Center;

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Elena Ratner Yale Cancer Center/Smilow Cancer Hospital;

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Steven W. Remmenga Fred & Pamela Buffett Cancer Center;

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Roberto Vargas Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

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Theresa L. Werner Huntsman Cancer Institute at the University of Utah;

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Emese Zsiros Roswell Park Comprehensive Cancer Center; and

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Jennifer L. Burns National Comprehensive Cancer Network

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Anita M. Engh National Comprehensive Cancer Network

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Volume/Issue:
Volume 19: Issue 2
Online Publication Date:
02 Feb 2021
DOI:
https://doi.org/10.6004/jnccn.2021.0007
Restricted access

Epithelial ovarian cancer is the leading cause of death from gynecologic cancer in the United States and is the country’s fifth most common cause of cancer mortality in women. A major challenge in treating ovarian cancer is that most patients have advanced disease at initial diagnosis. These NCCN Guidelines discuss cancers originating in the ovary, fallopian tube, or peritoneum, as these are all managed in a similar manner. Most of the recommendations are based on data from patients with the most common subtypes─high-grade serous and grade 2/3 endometrioid. The NCCN Guidelines also include recommendations specifically for patients with less common ovarian cancers, which in the guidelines include the following: carcinosarcoma, clear cell carcinoma, mucinous carcinoma, low-grade serous, grade 1 endometrioid, borderline epithelial, malignant sex cord-stromal, and malignant germ cell tumors. This manuscript focuses on certain aspects of primary treatment, including primary surgery, adjuvant therapy, and maintenance therapy options (including PARP inhibitors) after completion of first-line chemotherapy.

Individual Disclosures for the NCCN Ovarian Cancer Panel

T15

Supplementary Materials

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Print ISSN:
1540-1405
Online ISSN:
1540-1413
Publisher:
National Comprehensive Cancer Network
Cover Journal of the National Comprehensive Cancer Network
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