Cancer-Associated Venous Thromboembolic Disease, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology

Authors:
Michael B. StreiffThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

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Bjorn HolmstromMoffitt Cancer Center;

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Dana AngeliniCase Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

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Aneel AshraniMayo Clinic Cancer Center;

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Amro ElshouryRoswell Park Comprehensive Cancer Center;

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John FanikosDana-Farber/Brigham and Women′s Cancer Center;

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Kleber Yotsumoto FertrinFred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

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Annemarie E. FogertyMassachusetts General Hospital Cancer Center;

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Shuwei GaoThe University of Texas MD Anderson Cancer Center;

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Samuel Z. GoldhaberDana-Farber/Brigham and Women′s Cancer Center;

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Krishna GundaboluFred & Pamela Buffett Cancer Center;

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Ibrahim IbrahimUT Southwestern Simmons Comprehensive Cancer Center;

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Eric KrautOhio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

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Andrew D. LeavittUCSF Helen Diller Family Comprehensive Cancer Center;

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Alfred LeeYale Cancer Center/Smilow Cancer Hospital;

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Jason T. LeeStanford Cancer Institute;

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Ming LimHuntsman Cancer Institute at the University of Utah;

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Janelle MannSiteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

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Karlyn MartinRobert H. Lurie Comprehensive Cancer Center of Northwestern University;

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Brandon McMahonUniversity of Colorado Cancer Center;

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John MoriartyUCLA Jonsson Comprehensive Cancer Center;

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Colleen MortonVanderbilt-Ingram Cancer Center;

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Thomas L. OrtelDuke Cancer Institute;

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Rita PaschalO’Neal Comprehensive Cancer Center at UAB;

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Jordan SchaeferUniversity of Michigan Rogel Cancer Center;

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Sanford ShattilUC San Diego Moores Cancer Center;

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Tanya SiddiqiCity of Hope National Medical Center;

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Deepak SudheendraAbramson Cancer Center at the University of Pennsylvania;

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Eliot WilliamsUniversity of Wisconsin Carbone Cancer Center; and

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Liz HollingerNational Comprehensive Cancer Network

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Mai Q. NguyenNational Comprehensive Cancer Network

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NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Cancer-Associated Venous Thromboembolic Disease focus on the prevention, diagnosis, and treatment of patients with cancer who have developed or who are at risk for developing venous thromboembolism (VTE). VTE is a significant concern among cancer patients, who are at heightened risks for developing as well as dying from the disease. The management of patients with cancer with VTE often requires multidisciplinary efforts at treating institutions. The NCCN panel comprises specialists from various fields: cardiology, hematology/hematologic oncology, internal medicine, interventional radiology, medical oncology, pharmacology/pharmacy, and surgery/surgical oncology. This article focuses on VTE prophylaxis for medical and surgical oncology inpatients and outpatients, and discusses risk factors for VTE development, risk assessment tools, as well as management methods, including pharmacological and mechanical prophylactics. Contraindications to therapeutic interventions and special dosing, when required, are also discussed.

Individual Disclosures for the NCCN Cancer-Associated Venous Thromboembolic Disease Panel

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