NCCN Guidelines Insights: Rectal Cancer, Version 6.2020

Featured Updates to the NCCN Guidelines

Authors:
Al B. Benson III Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

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Alan P. Venook UCSF Helen Diller Family Comprehensive Cancer Center;

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Mahmoud M. Al-Hawary University of Michigan Rogel Cancer Center;

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Mustafa A. Arain UCSF Helen Diller Family Comprehensive Cancer Center;

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Yi-Jen Chen City of Hope National Medical Center;

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Kristen K. Ciombor Vanderbilt-Ingram Cancer Center;

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Stacey Cohen Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

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Harry S. Cooper Fox Chase Cancer Center;

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Dustin Deming University of Wisconsin Carbone Cancer Center;

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Ignacio Garrido-Laguna Huntsman Cancer Institute at the University of Utah;

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Jean L. Grem Fred & Pamela Buffett Cancer Center;

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Andrew Gunn O’Neal Comprehensive Cancer Center at UAB;

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Sarah Hoffe Moffitt Cancer Center;

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Joleen Hubbard Mayo Clinic Cancer Center;

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Steven Hunt Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

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Natalie Kirilcuk Stanford Cancer Institute;

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Smitha Krishnamurthi Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

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Wells A. Messersmith University of Colorado Cancer Center;

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Jeffrey Meyerhardt Dana-Farber/Brigham and Women’s Cancer Center;

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Eric D. Miller The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

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Mary F. Mulcahy Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

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Steven Nurkin Roswell Park Comprehensive Cancer Center;

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Michael J. Overman The University of Texas MD Anderson Cancer Center;

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Aparna Parikh Massachusetts General Hospital Cancer Center;

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Hitendra Patel UC San Diego Moores Cancer Center;

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Katrina Pedersen Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

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Leonard Saltz Memorial Sloan Kettering Cancer Center;

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Charles Schneider Abramson Cancer Center at the University of Pennsylvania;

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David Shibata The University of Tennessee Health Science Center;

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John M. Skibber The University of Texas MD Anderson Cancer Center;

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Constantinos T. Sofocleous Memorial Sloan Kettering Cancer Center;

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Elena M. Stoffel University of Michigan Rogel Cancer Center;

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Eden Stotsky-Himelfarb The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

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Christopher G. Willett Duke Cancer Institute; and

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Alyse Johnson-Chilla National Comprehensive Cancer Network.

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Lisa A. Gurski National Comprehensive Cancer Network.

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The NCCN Guidelines for Rectal Cancer provide recommendations for the diagnosis, evaluation, treatment, and follow-up of patients with rectal cancer. These NCCN Guidelines Insights summarize the panel discussion behind recent important updates to the guidelines. These updates include clarifying the definition of rectum and differentiating the rectum from the sigmoid colon; the total neoadjuvant therapy approach for localized rectal cancer; and biomarker-targeted therapy for metastatic colorectal cancer, with a focus on new treatment options for patients with BRAF V600E– or HER2 amplification–positive disease.

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