Bladder Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology

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Thomas W. Flaig University of Colorado Cancer Center;

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Philippe E. Spiess Moffitt Cancer Center;

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Neeraj Agarwal Huntsman Cancer Institute at the University of Utah;

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Rick Bangs Patient Advocate;

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Stephen A. Boorjian Mayo Clinic Cancer Center;

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Mark K. Buyyounouski Stanford Cancer Institute;

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Sam Chang Vanderbilt-Ingram Cancer Center;

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Tracy M. Downs University of Wisconsin Carbone Cancer Center;

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Jason A. Efstathiou Massachusetts General Hospital Cancer Center;

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Terence Friedlander UCSF Helen Diller Family Comprehensive Cancer Center;

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Richard E. Greenberg Fox Chase Cancer Center;

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Khurshid A. Guru Roswell Park Comprehensive Cancer Center;

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Thomas Guzzo Abramson Cancer Center at the University of Pennsylvania;

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Harry W. Herr Memorial Sloan Kettering Cancer Center;

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Jean Hoffman-Censits The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

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Christopher Hoimes Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

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Brant A. Inman Duke Cancer Institute;

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Masahito Jimbo University of Michigan Rogel Cancer Center;

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A. Karim Kader UC San Diego Moores Cancer Center;

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Subodh M. Lele Fred & Pamela Buffett Cancer Center;

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Jeff Michalski Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

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Jeffrey S. Montgomery University of Michigan Rogel Cancer Center;

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Lakshminarayanan Nandagopal O'Neal Comprehensive Cancer Center at UAB;

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Lance C. Pagliaro Mayo Clinic Cancer Center;

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Sumanta K. Pal City of Hope National Medical Center;

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Anthony Patterson St. Jude Children’s Research Hospital/The University of Tennessee Health Science Center;

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Elizabeth R. Plimack Fox Chase Cancer Center;

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Kamal S. Pohar The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

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Mark A. Preston Dana-Farber/Brigham and Women’s Cancer Center;

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Wade J. Sexton Moffitt Cancer Center;

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Arlene O. Siefker-Radtke The University of Texas MD Anderson Cancer Center;

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Jonathan Tward Huntsman Cancer Institute at the University of Utah;

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Jonathan L. Wright Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; and

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Lisa A. Gurski National Comprehensive Cancer Network

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Alyse Johnson-Chilla National Comprehensive Cancer Network

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This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Bladder Cancer focuses on the clinical presentation and workup of suspected bladder cancer, treatment of non–muscle-invasive urothelial bladder cancer, and treatment of metastatic urothelial bladder cancer because important updates have recently been made to these sections. Some important updates include recommendations for optimal treatment of non–muscle-invasive bladder cancer in the event of a bacillus Calmette-Guérin (BCG) shortage and details about biomarker testing for advanced or metastatic disease. The systemic therapy recommendations for second-line or subsequent therapies have also been revised. Treatment and management of muscle-invasive, nonmetastatic disease is covered in the complete version of the NCCN Guidelines for Bladder Cancer available at NCCN.org. Additional topics covered in the complete version include treatment of nonurothelial histologies and recommendations for nonbladder urinary tract cancers such as upper tract urothelial carcinoma, urothelial carcinoma of the prostate, and primary carcinoma of the urethra.

Individual Disclosures for the NCCN Bladder Cancer Panel

TU1

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