NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities, Version 1.2020

Featured Updates to the NCCN Guidelines

Authors:
John A. Thompson Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

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Bryan J. Schneider University of Michigan Rogel Cancer Center;

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Julie Brahmer The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

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Stephanie Andrews Moffitt Cancer Center;

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Philippe Armand Dana-Farber/Brigham and Women’s Cancer Center;

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Shailender Bhatia Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

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Lihua E. Budde City of Hope National Medical Center;

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Luciano Costa O’Neal Comprehensive Cancer Center at UAB;

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Marianne Davies Yale Cancer Center/Smilow Cancer Hospital;

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David Dunnington Patient Advocate;

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Marc S. Ernstoff Roswell Park Comprehensive Cancer Center;

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Matthew Frigault Massachusetts General Hospital Cancer Center;

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Benjamin H. Kaffenberger The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

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Matthew Lunning Fred & Pamela Buffett Cancer Center;

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Suzanne McGettigan Abramson Cancer Center at the University of Pennsylvania;

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Jordan McPherson Huntsman Cancer Institute at the University of Utah;

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Nisha A. Mohindra Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

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Jarushka Naidoo The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

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Anthony J. Olszanski Fox Chase Cancer Center;

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Olalekan Oluwole Vanderbilt-Ingram Cancer Center;

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Sandip P. Patel UC San Diego Moores Cancer Center;

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Nathan Pennell Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

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Sunil Reddy Stanford Cancer Institute;

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Mabel Ryder Mayo Clinic Cancer Center;

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Bianca Santomasso Memorial Sloan Kettering Cancer Center;

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Scott Shofer Duke Cancer Institute;

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Jeffrey A. Sosman Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

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Yinghong Wang The University of Texas MD Anderson Cancer Center;

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Ryan M. Weight University of Colorado Cancer Center; and

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Alyse Johnson-Chilla National Comprehensive Cancer Network.

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Griselda Zuccarino-Catania National Comprehensive Cancer Network.

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Anita Engh National Comprehensive Cancer Network.

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The NCCN Guidelines for Management of Immunotherapy-Related Toxicities provide interdisciplinary guidance on the management of immune-related adverse events (irAEs) resulting from cancer immunotherapy. These NCCN Guidelines Insights describe symptoms that may be caused by an irAE and should trigger further investigation, and summarize the NCCN Management of Immunotherapy-Related Toxicities Panel discussions for the 2020 update to the guidelines regarding immune checkpoint inhibitor–related diarrhea/colitis and cardiovascular irAEs.

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  • 2.

    Opdivo (nivolumab) injection, for intravenous use [prescribing information]. Princeton, NJ: Bristol-Myers Squibb Company; 2019. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/125554s075lbl.pdf. Accessed September 1, 2019.

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  • 3.

    Tecentriq (atezolizumab) injection, for intravenous use [prescribing information]. South San Francisco, CA: Genentech, Inc.; 2019. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/761034s021lbl.pdf. Accessed December 1, 2019.

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  • 4.

    Bavencio (avelumab) injection, for intravenous use [prescribing information]. Rockland, MA: EMD Serono, Inc; 2019. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/761049s006lbl.pdf. Accessed May 1, 2019.

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  • 5.

    Yervoy (ipilimumab) injection, for intravenous use [prescribing information]. Princeton, NJ: Bristol-Myers Squibb Company; 2019. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/125377s104lbl.pdf. Accessed September 1, 2019.

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  • 6.

    Imfinzi (durvalumab) injection, for intravenous use [prescribing information]. Cambridge, England: AstraZeneca UK Limited; 2019. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/761069s013lbl.pdf. Accessed July 2019.

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