Relationship Between Quality of Life and Survival in Patients With Pancreatic and Periampullary Cancer: A Multicenter Cohort Analysis

Tara M. Mackay; Anouk E.J. Latenstein; Mirjam A.G. Sprangers; Lydia G. van der Geest; Geert-Jan Creemers; Susan van Dieren; Jan-Willem B. de Groot; Bas Groot Koerkamp; Ignace H. de Hingh; Marjolein Y.V. Homs; Evelien J.M. de Jong; I. Quintus Molenaar; Gijs A. Patijn; Lonneke V. van de Poll-Franse; Hjalmar C. van Santvoort; Judith de Vos-Geelen; Johanna W. Wilmink; Casper H. van Eijck; Marc G. Besselink; Hanneke W.M. van Laarhoven

doi:10.6004/jnccn.2020.7579

Relationship Between Quality of Life and Survival in Patients With Pancreatic and Periampullary Cancer: A Multicenter Cohort Analysis

Authors:

Tara M. Mackay

Tara M. Mackay Department of Surgery, and

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Anouk E.J. Latenstein

Anouk E.J. Latenstein Department of Surgery, and

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Mirjam A.G. Sprangers

Mirjam A.G. Sprangers Department of Medical Psychology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam;

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MSc

Lydia G. van der Geest

Lydia G. van der Geest Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht;

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MSc, PhD

Geert-Jan Creemers

Geert-Jan Creemers Department of Medical Oncology, Catharina Hospital, Eindhoven;

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MD, PhD

Susan van Dieren

Susan van Dieren Department of Surgery, and

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MSc, PhD

Jan-Willem B. de Groot

Jan-Willem B. de Groot Department of Medical Oncology, Isala Hospital, Zwolle;

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MD, PhD

Bas Groot Koerkamp

Bas Groot Koerkamp Department of Surgery, Erasmus Medical Center, Rotterdam;

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MD, PhD, MSc

Ignace H. de Hingh

Ignace H. de Hingh Department of Surgery, Catharina Hospital, Eindhoven;

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MD, PhD

Marjolein Y.V. Homs

Marjolein Y.V. Homs Department of Medical Oncology, Erasmus Medical Center, Rotterdam;

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MD, PhD

Evelien J.M. de Jong

Evelien J.M. de Jong Department of Internal Medicine, Division of Medical Oncology, GROW-School for Oncology and Developmental Biology, Maastricht UMC+, Maastricht;

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BSc

I. Quintus Molenaar

I. Quintus Molenaar Department of Surgery, Regional Academic Cancer Center Utrecht, UMC Utrecht Cancer Center and St. Antonius Hospital, Utrecht;

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MD, PhD

Gijs A. Patijn

Gijs A. Patijn Department of Surgery, Isala Hospital, Zwolle;

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MD, PhD

Lonneke V. van de Poll-Franse

Lonneke V. van de Poll-Franse Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht;
Division of Psychosocial Research & Epidemiology, Netherlands Cancer Institute, Amsterdam;
Department of Medical and Clinical Psychology, Tilburg University, Tilburg; and

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PhD

Hjalmar C. van Santvoort

Hjalmar C. van Santvoort Department of Surgery, Regional Academic Cancer Center Utrecht, UMC Utrecht Cancer Center and St. Antonius Hospital, Utrecht;

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MD, PhD

Judith de Vos-Geelen

Judith de Vos-Geelen Department of Internal Medicine, Division of Medical Oncology, GROW-School for Oncology and Developmental Biology, Maastricht UMC+, Maastricht;

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Johanna W. Wilmink

Johanna W. Wilmink Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

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MD, PhD

Casper H. van Eijck

Casper H. van Eijck Department of Surgery, Erasmus Medical Center, Rotterdam;

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MD, PhD

Marc G. Besselink

Marc G. Besselink Department of Surgery, and

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MD, PhD

Hanneke W.M. van Laarhoven

Hanneke W.M. van Laarhoven Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

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MD, PhD

, and

for the Dutch Pancreatic Cancer Group

for the Dutch Pancreatic Cancer Group
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Volume/Issue:: Volume 18: Issue 10

Online Publication Date:: 01 Oct 2020

DOI:: https://doi.org/10.6004/jnccn.2020.7579

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Background: A relationship between quality of life (QoL) and survival has been shown for several types of cancer, mostly in clinical trials with highly selected patient groups. The relationship between QoL and survival for patients with pancreatic or periampullary cancer is unclear. Methods: This study analyzed QoL data from a prospective multicenter patient-reported outcome registry in patients with pancreatic or periampullary carcinoma registered in the nationwide Netherlands Cancer Registry (2015–2018). Baseline and delta QoL, between baseline and 3-month follow-up, were assessed with the Happiness, EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30), and QLQ-PAN26 questionnaires. The relationship between QoL and survival was assessed using Cox regression models, and additional prognostic value of separate items was assessed using Nagelkerke R ² (explained variance). Results: For the baseline and delta analyses, 233 and 148 patients were available, respectively. Most were diagnosed with pancreatic adenocarcinoma (n=194; 83.3%) and had stage III disease (n=77; 33.0%), with a median overall survival of 13.6 months. Multivariate analysis using baseline scores indicated several scales to be of prognostic value for the total cohort (ie, happiness today, role functioning, diarrhea, pancreatic pain, and body image; hazard ratios all P<.05) and for patients without resection (ie, overall satisfaction with life, physical and cognitive functioning, QLQ-C30 summary score, fatigue, pain, constipation, diarrhea, and body image; hazard ratios all P<.05). Except for diarrhea, all QoL items accounted for >5% of the additional explained variance and were of added prognostic value. Multivariate analysis using delta QoL revealed that only constipation was of prognostic value for the total cohort, whereas no association with survival was found for subgroups with or without resection. Conclusions: In a multicenter cohort of patients with pancreatic or periampullary carcinoma, QoL scores predicted survival regardless of patient, tumor, and treatment characteristics. QoL scores may thus be used for shared decision-making regarding disease management and treatment choice.

Submitted January 29, 2020; accepted for publication April 21, 2020.

Author contributions: Study concept or design: Mackay, Latenstein, van der Geest, Besselink, van Laarhoven. Data acquisition or analysis: Mackay, Latenstein, van der Geest, Besselink, van Laarhoven. Data interpretation: All authors. Manuscript preparation or critical revision: All authors.

Disclosures: The authors have disclosed that they have not received any financial consideration from any person or organization to support the preparation, analysis, results, or discussion of this article.

Funding: This work was supported by funding from KWF Kankerbestrijding (UVA2013-5842).

Correspondence: Hanneke W.M. van Laarhoven, MD, PhD, Department of Medical Oncology, D3-312, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. Email: h.vanlaarhoven@amsterdamumc.nl

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Journal of the National Comprehensive Cancer Network

Print ISSN:: 1540-1405

Online ISSN:: 1540-1413

Publisher:: National Comprehensive Cancer Network

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Page Numbers:: 10

Article Category:: Research Article

Received:: 29 Jan 2020

Accepted:: 21 Apr 2020

Print Publication Date:: 01 Oct 2020

Online Publication Date:: 01 Oct 2020

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