A Cryptic BCR-PDGFRB Fusion Resulting in a Chronic Myeloid Neoplasm With Monocytosis and Eosinophilia: A Novel Finding With Treatment Implications

Authors:
Sanjeev Kumar Gupta Departments of Leukemia,

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Nitin Jain Departments of Leukemia,

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Guilin Tang Hematopathology, and

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Andrew Futreal Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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Sa A. Wang Hematopathology, and

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Joseph D. Khoury Hematopathology, and

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Richard K. Yang Hematopathology, and

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Hong Fang Hematopathology, and

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Keyur P. Patel Hematopathology, and

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Rajyalakshmi Luthra Hematopathology, and

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Mark Routbort Hematopathology, and

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Bedia A. Barkoh Hematopathology, and

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Wei Chen Hematopathology, and

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Xizeng Mao Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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Jianhua Zhang Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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L. Jeffrey Medeiros Hematopathology, and

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Carlos E. Bueso-Ramos Hematopathology, and

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Sanam Loghavi Hematopathology, and

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Volume/Issue:
Volume 18: Issue 10
Online Publication Date:
01 Oct 2020
DOI:
https://doi.org/10.6004/jnccn.2020.7573
Restricted access

RNA-seq was used to identify the partner gene and confirm the presence of a BCR-PDGFRB fusion. Identification of this fusion product resulted in successful treatment and long-term remission of this myeloid neoplasm. Based on our results, we suggest that despite current WHO recommendations, screening for PDGFRB rearrangement in cases of leukocytosis with eosinophilia and no other etiologic explanation is necessary, even if the karyotype is normal.

Submitted February 6, 2020; accepted for publication April 6, 2020.

Author contributions: Study concept and design: Jain, Bueso-Ramos, Loghavi. Patient treatment: Jain. Pathologic workup and case characterization: Tang, Wang, Khoury, Futreal, Bueso-Ramos, Medeiro, Patel. RNA-seq studies and data analysis: Futreal, Barkoh, Chen, Mao, Zhang. Manuscript preparation: All authors.

Disclosures: The authors have disclosed that they have not received any financial consideration from any person or organization to support the preparation, analysis, results, or discussion of this article

Correspondence: Sanam Loghavi, MD, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, 0072, Houston, TX 77030. Email: sloghavi@mdanderson.org
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Print ISSN:
1540-1405
Online ISSN:
1540-1413
Publisher:
National Comprehensive Cancer Network
Cover Journal of the National Comprehensive Cancer Network
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Copyright:
Copyright © 2020 by the National Comprehensive Cancer Network 2020
Page Numbers:
5
Article Category:
Other
Received:
06 Feb 2020
Accepted:
06 Apr 2020
Print Publication Date:
01 Oct 2020
Online Publication Date:
01 Oct 2020

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