Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology

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Al B. Benson III Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

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Alan P. Venook UCSF Helen Diller Family Comprehensive Cancer Center;

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Mahmoud M. Al-Hawary University of Michigan Rogel Cancer Center;

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Mustafa A. Arain UCSF Helen Diller Family Comprehensive Cancer Center;

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Yi-Jen Chen City of Hope National Medical Center;

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Kristen K. Ciombor Vanderbilt-Ingram Cancer Center;

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Stacey A. Cohen Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

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Harry S. Cooper Fox Chase Cancer Center;

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Dustin A. Deming University of Wisconsin Carbone Cancer Center;

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Ignacio Garrido-Laguna Huntsman Cancer Institute at the University of Utah;

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Jean L. Grem Fred & Pamela Buffett Cancer Center;

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Sarah E. Hoffe Moffitt Cancer Center;

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Joleen Hubbard Mayo Clinic Cancer Center;

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Steven Hunt Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

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Ahmed Kamel O'Neal Comprehensive Cancer Center at UAB;

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Natalie Kirilcuk Stanford Cancer Institute;

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Smitha Krishnamurthi Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

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Wells A. Messersmith University of Colorado Cancer Center;

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Jeffrey Meyerhardt Dana-Farber/Brigham and Women’s Cancer Center;

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Eric D. Miller The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

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Mary F. Mulcahy Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

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Steven Nurkin Roswell Park Comprehensive Cancer Center;

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Michael J. Overman The University of Texas MD Anderson Cancer Center;

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Aparna Parikh Massachusetts General Hospital Cancer Center;

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Hitendra Patel UC San Diego Moores Cancer Center;

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Katrina S. Pedersen Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

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Leonard B. Saltz Memorial Sloan Kettering Cancer Center;

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Charles Schneider Abramson Cancer Center at the University of Pennsylvania;

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David Shibata The University of Tennessee Health Science Center;

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John M. Skibber The University of Texas MD Anderson Cancer Center;

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Constantinos T. Sofocleous Memorial Sloan Kettering Cancer Center;

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Elena M. Stoffel University of Michigan Rogel Cancer Center;

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Eden Stotsky-Himelfarb The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

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Christopher G. Willett Duke Cancer Institute; and

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Alyse Johnson-Chilla National Comprehensive Cancer Network

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Kristina M. Gregory National Comprehensive Cancer Network

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Lisa A. Gurski National Comprehensive Cancer Network

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Small bowel adenocarcinoma (SBA) is a rare malignancy of the gastrointestinal tract that has increased in incidence across recent years. Often diagnosed at an advanced stage, outcomes for SBA are worse on average than for other related malignancies, including colorectal cancer. Due to the rarity of this disease, few studies have been done to direct optimal treatment, although recent data have shown that SBA responds to treatment differently than colorectal cancer, necessitating a separate approach to treatment. The NCCN Guidelines for Small Bowel Adenocarcinoma were created to establish an evidence-based standard of care for patients with SBA. These guidelines provide recommendations on the workup of suspected SBA, primary treatment options, adjuvant treatment, surveillance, and systemic therapy for metastatic disease. Additionally, principles of imaging and endoscopy, pathologic review, surgery, radiation therapy, and survivorship are described.

Individual Disclosures for the NCCN Small Bowel Adenocarcinoma Panel

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