NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019

Featured Updates to the NCCN Guidelines

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Samir Gupta UC San Diego Moores Cancer Center;

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Dawn Provenzale Duke Cancer Institute;

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Xavier Llor Yale Cancer Center/Smilow Cancer Hospital;

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Amy L. Halverson Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

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William Grady Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

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Daniel C. Chung Massachusetts General Hospital Cancer Center;

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Sigurdis Haraldsdottir Stanford Cancer Institute;

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Arnold J. Markowitz Memorial Sloan Kettering Cancer Center;

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Thomas P. Slavin Jr City of Hope National Medical Center;

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Heather Hampel
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CGC The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

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Reid M. Ness Vanderbilt-Ingram Cancer Center;

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Jennifer M. Weiss University of Wisconsin Carbone Cancer Center;

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Dennis J. Ahnen University of Colorado Cancer Center;

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Lee-may Chen UCSF Helen Diller Family Comprehensive Cancer Center;

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Gregory Cooper Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

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Dayna S. Early Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

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Francis M. Giardiello The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

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Michael J. Hall Fox Chase Cancer Center;

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Stanley R. Hamilton The University of Texas MD Anderson Cancer Center;

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Priyanka Kanth Huntsman Cancer Institute at the University of Utah;

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Jason B. Klapman Moffitt Cancer Center;

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Audrey J. Lazenby Fred & Pamela Buffett Cancer Center;

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Patrick M. Lynch The University of Texas MD Anderson Cancer Center;

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Robert J. Mayer Dana-Farber/Brigham and Women’s Cancer Center;

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June Mikkelson
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CGC Roswell Park Comprehensive Cancer Center;

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Shajan Peter O'Neal Comprehensive Cancer Center at UAB;

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Scott E. Regenbogen University of Michigan Rogel Cancer Center; and

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Mary A. Dwyer
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CGC National Comprehensive Cancer Network.

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Ndiya Ogba National Comprehensive Cancer Network.

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Identifying individuals with hereditary syndromes allows for improved cancer surveillance, risk reduction, and optimized management. Establishing criteria for assessment allows for the identification of individuals who are carriers of pathogenic genetic variants. The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal provide recommendations for the assessment and management of patients with high-risk colorectal cancer syndromes. These NCCN Guidelines Insights focus on criteria for the evaluation of Lynch syndrome and considerations for use of multigene testing in the assessment of hereditary colorectal cancer syndromes.

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    Hampel H, Frankel WL, Martin E, et al.. Feasibility of screening for Lynch syndrome among patients with colorectal cancer. J Clin Oncol 2008;26:57835788.

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