Challenges With the 8th Edition of the AJCC Cancer Staging Manual for Breast, Testicular, and Head and Neck Cancers

Authors:
Aysegul A. Sahin
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 MD
,
Timothy D. Gilligan
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 MD
, and
Jimmy J. Caudell
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 MD, PhD
Volume/Issue:
Volume 17: Issue 5.5
Online Publication Date:
May 2019
DOI:
https://doi.org/10.6004/jnccn.2019.5015
Restricted access

Three experts discussed changes in the 8th edition of the AJCC Cancer Staging Manual and challenges regarding these changes for staging of breast cancer, testicular cancer, and head and neck cancer, respectively. In general, the staging changes for breast cancer and for human papillomavirus–positive oropharyngeal cancer were hailed as improvements, but the changes for testicular cancer were questioned as to their clinical relevance. Better studies are needed to improve staging for human papillomavirus–negative oropharyngeal cancer.

Correspondence: Aysegul A. Sahin, MD, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 0085, Room G1.35, Houston TX 77030. Email: asahin@mdanderson.org; Timothy D. Gilligan, MD, Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Avenue, CA-60, Cleveland OH 44195. Email: gilligt@ccf.org; and Jimmy J. Caudell, MD, PhD, Moffitt Cancer Center, 12902 Magnolia Drive, Department of Radiation Oncology, Tampa FL, 33612. Email: jimmy.caudell@moffitt.org
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Print ISSN:
1540-1405
Online ISSN:
1540-1413
Publisher:
National Comprehensive Cancer Network
Cover Journal of the National Comprehensive Cancer Network
  • 1.

    Amin MB, Edge SB, Greene FL, et al. AJCC Cancer Staging Manual, Eighth Edition. Chicago, IL: American Joint Committee on Cancer; 2018.

  • 2.

    Yi M, Mittendorf EA, Cormier JN, et al. Novel staging system for predicting disease-free survival in patients with breast cancer treated with surgery as the first intervention: time to modify the current American Joint Committee on Cancer Staging System. J Clin Oncol 2011;29:4654–4661.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Mittendorf EA, Chavez-McGregor M, Vila J, et al. Bioscore: a staging system for breast cancer patients that reflects the prognostic significance of underlying tumor biology. Ann Surg Oncol 2017;24:3502–3509.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Weiss A, Chavez-MacGregor M, Lichtensztajn DY, et al. Validation study of the American Joint Committee on Cancer eighth edition prognostic stage compared with the anatomic stage in breast cancer. JAMA Oncol 2018;4:203–209.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Tandstad T, Stähl O, Dahl O, et al. Treatment of stage I seminoma, with one course of adjuvant carboplatin or surveillance, risk-adapted recommendations implemented patient autonomy: a report from the Swedish and Norwegian Testicular Cancer Group (SWENOTECA). Ann Oncol 2016;27:1299–1304.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Sanmamed MF, Esteban E, Uriol E, et al. Epidermal growth factor receptor and epididymis invasion as prognostic biomarkers in clinical stage I testicular germ tumours. J Transl Med 2017;15:62.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Soper MS, Hastings JR, Cosmatos HA, et al. Observation versus adjuvant radiation or chemotherapy in the management of stage I seminoma: clinical outcomes and prognostic factors for relapse in a large US cohort. Am J Clin Oncol 2014;37:356–359.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Yilmaz A, Cheng T, Zhang J, Trpkov K. Testicular hilum and vascular invasion predict advanced clinical stage in nonseminomatous germ cell tumors. Mod Pathol 2013;26:579–586.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Verrill C, Yilmaz A, Srigley JR, et al. Reporting and staging of testicular germ cell tumors: the International Society of Urological Pathology (ISUP) Testicular Cancer Consultation Conference recommendations. Am J Surg Pathol 2017;41:22–32.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    O’Sullivan B, Huang SH, Su J, et al. Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal Cancer Network for Staging (ICON-S): a multicenter cohort study. Lancet Oncol 2016;17:440–451.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Gillison M, Trotti AM, Harris J, et al. Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomized, multicenter, non-inferiority trial. Lancet 2019;393:40–50.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Pfister DG, Spencer S, Adelstein D, et al. NCCN Clinical Practice Guidelines in Oncology: Head and Neck Cancers. Version 1.2019. Accessed April 19, 2019. To view the most recent version of these guidelines, visit NCCN.org.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Lydiatt WM, Patel SG, O’Sullivan B, et al. Head and neck cancers – major changes in the American Joint Committee on Cancer eighth edition staging manual. CA Cancer J 2017;67:122–137.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
Copyright:
Copyright © 2019 by the National Comprehensive Cancer Network 2019
Page Numbers:
5
Article Category:
Research Article
Print Publication Date:
01 May 2019
Online Publication Date:
May 2019

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