Heterogeneity in Microsatellite Instability in Metastatic Colorectal Cancer: Mechanisms and Clinical Implications

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Rona Yaeger
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  • 1.

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    Overman MJ, McDermott R, Leach JL, et al.. Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study. Lancet Oncol 2017;18:11821191.

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    Overman MJ, Lonardi S, Wong KYM, et al.. Durable clinical benefit with nivolumab plus ipilimumab in DNA mismatch repair-deficient/microsatellite instability-high metastatic colorectal cancer. J Clin Oncol 2018;36:773779.

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