NCCN Guidelines Insights: Non–Small Cell Lung Cancer, Version 5.2018

Authors:
David S. Ettinger The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Dara L. Aisner The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Douglas E. Wood The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Wallace Akerley The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Jessica Bauman The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Joe Y. Chang The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Lucian R. Chirieac The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Thomas A. D'Amico The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Thomas J. Dilling The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Michael Dobelbower The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Ramaswamy Govindan The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Matthew A. Gubens The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Mark Hennon The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Leora Horn The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Rudy P. Lackner The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Michael Lanuti The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Ticiana A. Leal The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Rogerio Lilenbaum The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Jules Lin The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Billy W. Loo Jr The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Renato Martins The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Gregory A. Otterson The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Sandip P. Patel The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Karen Reckamp The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Gregory J. Riely The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Steven E. Schild The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Kurt Tauer The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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Miranda Hughes The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Colorado Cancer Center; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; Fox Chase Cancer Center; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Wisconsin Carbone Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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The NCCN Guidelines for Non–Small Cell Lung Cancer (NSCLC) address all aspects of management for NSCLC. These NCCN Guidelines Insights focus on recent updates to the targeted therapy and immunotherapy sections in the NCCN Guidelines. For the 2018 update, a new section on biomarkers was added.

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