Merkel Cell Carcinoma, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology

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This selection from the NCCN Guidelines for Merkel Cell Carcinoma (MCC) focuses on areas impacted by recently emerging data, including sections describing MCC risk factors, diagnosis, workup, follow-up, and management of advanced disease with radiation and systemic therapy. Included in these sections are discussion of the new recommendations for use of Merkel cell polyomavirus as a biomarker and new recommendations for use of checkpoint immunotherapies to treat metastatic or unresectable disease. The next update of the complete version of the NCCN Guidelines for MCC will include more detailed information about elements of pathology and addresses additional aspects of management of MCC, including surgical management of the primary tumor and draining nodal basin, radiation therapy as primary treatment, and management of recurrence.

Please Note

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) are a statement of consensus of the authors regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult the NCCN Guidelines® is expected to use independent medical judgment in the context of individual clinical circumstances to determine any patient's care or treatment. The National Comprehensive Cancer Network® (NCCN®) makes no representation or warranties of any kind regarding their content, use, or application and disclaims any responsibility for their applications or use in any way. The full NCCN Guidelines for Merkel Cell Carcinoma are not printed in this issue of JNCCN but can be accessed online at NCCN.org.

© National Comprehensive Cancer Network, Inc. 2018, All rights reserved. The NCCN Guidelines and the illustrations herein may not be reproduced in any form without the express written permission of NCCN.

Disclosures for the NCCN Merkel Cell Carcinoma Panel

At the beginning of each NCCN Guidelines panel meeting, panel members review all potential conflicts of interest. NCCN, in keeping with its commitment to public transparency, publishes these disclosures for panel members, staff, and NCCN itself.

Individual disclosures for the NCCN Merkel Cell Carcinoma Panel members can be found on page 774. (The most recent version of these guidelines and accompanying disclosures are available on the NCCN Web site at NCCN.org.)

These guidelines are also available on the Internet. For the latest update, visit NCCN.org.

NCCN Merkel Cell Carcinoma Panel Members

*Christopher K. Bichakjian, MD/Chairϖ

University of Michigan Rogel Cancer Center

Thomas Olencki, DO/Vice Chair†

The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute

Sumaira Z. Aasi, MDϖ

Stanford Cancer Institute

Murad Alam, MD, MBA, MSCIϖ¶ζ

Robert H. Lurie Comprehensive Cancer Center of Northwestern University

James S. Andersen, MD¶Ÿ

City of Hope Comprehensive Cancer Center

Rachel Blitzblau, MD, PhD§

Duke Cancer Center

Glen M. Bowen, MDϖ

Huntsman Cancer Institute at the University of Utah

Carlo M. Contreras, MD¶

University of Alabama at Birmingham Comprehensive Cancer Center

Gregory A. Daniels, MD, PhD†≠Þ

UC San Diego Moores Cancer Center

Roy Decker, MD, PhD§

Yale Cancer Center/Smilow Cancer Hospital

Jeffrey M. Farma, MD¶

Fox Chase Cancer Center

Kris Fisher, MDϖ≠

St. Jude Children's Research Hospital/The University of Tennessee Health Science Center

Brian Gastman, MDŸ

Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute

Karthik Ghosh, MDÞ

Mayo Clinic Cancer Center

Roy C. Grekin, MDϖ¶

UCSF Helen Diller Family Comprehensive Cancer Center

Kenneth Grossman, MD, PhD†

Huntsman Cancer Institute at the University of Utah

Alan L. Ho, MD, PhD†

Memorial Sloan Kettering Cancer Center

Karl D. Lewis, MD†

University of Colorado Cancer Center

Manisha Loss, MDϖ

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Daniel D. Lydiatt, DDS, MD¶

Fred & Pamela Buffett Cancer Center

Jane Messina, MD≠

Moffitt Cancer Center

Kishwer S. Nehal, MDϖ¶

Memorial Sloan Kettering Cancer Center

Paul Nghiem, MD, PhDϖ

University of Washington/Seattle Cancer Care Alliance

Igor Puzanov, MD, MSCI‡

Roswell Park Comprehensive Cancer Center

Chrysalyne D. Schmults, MD, MSϖ¶

Dana-Farber/Brigham and Women's Cancer Center

Ashok R. Shaha, MD¶ζ

Memorial Sloan Kettering Cancer Center

Valencia Thomas, MDϖ

The University of Texas MD Anderson Cancer Center

Yaohui G. Xu, MD, PhDϖ

University of Wisconsin Carbone Cancer Center

John A. Zic, MDϖ

Vanderbilt-Ingram Cancer Center

NCCN Staff: Karin G. Hoffmann, RN, CCM, and Anita M. Engh, PhD

KEY:

*Discussion Section Writing Committee

Specialties: ϖDermatology; ¶Surgery/Surgical Oncology; ζOtolaryngology; ≠Pathology/Dermatopathology; †Medical Oncology; ÞInternal Medicine; §Radiotherapy/Radiation Oncology; ŸReconstructive Surgery; ‡Hematology/Hematology Oncology

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