This selection from the NCCN Guidelines for Merkel Cell Carcinoma (MCC) focuses on areas impacted by recently emerging data, including sections describing MCC risk factors, diagnosis, workup, follow-up, and management of advanced disease with radiation and systemic therapy. Included in these sections are discussion of the new recommendations for use of Merkel cell polyomavirus as a biomarker and new recommendations for use of checkpoint immunotherapies to treat metastatic or unresectable disease. The next update of the complete version of the NCCN Guidelines for MCC will include more detailed information about elements of pathology and addresses additional aspects of management of MCC, including surgical management of the primary tumor and draining nodal basin, radiation therapy as primary treatment, and management of recurrence.

Please NoteThe NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) are a statement of consensus of the authors regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult the NCCN Guidelines® is expected to use independent medical judgment in the context of individual clinical circumstances to determine any patient's care or treatment. The National Comprehensive Cancer Network® (NCCN®) makes no representation or warranties of any kind regarding their content, use, or application and disclaims any responsibility for their applications or use in any way. The full NCCN Guidelines for Merkel Cell Carcinoma are not printed in this issue of JNCCN but can be accessed online at NCCN.org.© National Comprehensive Cancer Network, Inc. 2018, All rights reserved. The NCCN Guidelines and the illustrations herein may not be reproduced in any form without the express written permission of NCCN.
Disclosures for the NCCN Merkel Cell Carcinoma PanelAt the beginning of each NCCN Guidelines panel meeting, panel members review all potential conflicts of interest. NCCN, in keeping with its commitment to public transparency, publishes these disclosures for panel members, staff, and NCCN itself.Individual disclosures for the NCCN Merkel Cell Carcinoma Panel members can be found on page 774. (The most recent version of these guidelines and accompanying disclosures are available on the NCCN Web site at NCCN.org.)These guidelines are also available on the Internet. For the latest update, visit NCCN.org.
NCCN Merkel Cell Carcinoma Panel Members*Christopher K. Bichakjian, MD/ChairϖUniversity of Michigan Rogel Cancer CenterThomas Olencki, DO/Vice Chair†The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research InstituteSumaira Z. Aasi, MDϖStanford Cancer InstituteMurad Alam, MD, MBA, MSCIϖ¶ζRobert H. Lurie Comprehensive Cancer Center of Northwestern UniversityJames S. Andersen, MD¶ŸCity of Hope Comprehensive Cancer CenterRachel Blitzblau, MD, PhD§Duke Cancer CenterGlen M. Bowen, MDϖHuntsman Cancer Institute at the University of UtahCarlo M. Contreras, MD¶University of Alabama at Birmingham Comprehensive Cancer CenterGregory A. Daniels, MD, PhD†≠ÞUC San Diego Moores Cancer CenterRoy Decker, MD, PhD§Yale Cancer Center/Smilow Cancer HospitalJeffrey M. Farma, MD¶Fox Chase Cancer CenterKris Fisher, MDϖ≠St. Jude Children's Research Hospital/The University of Tennessee Health Science CenterBrian Gastman, MDŸCase Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer InstituteKarthik Ghosh, MDÞMayo Clinic Cancer CenterRoy C. Grekin, MDϖ¶UCSF Helen Diller Family Comprehensive Cancer CenterKenneth Grossman, MD, PhD†Huntsman Cancer Institute at the University of UtahAlan L. Ho, MD, PhD†Memorial Sloan Kettering Cancer CenterKarl D. Lewis, MD†University of Colorado Cancer CenterManisha Loss, MDϖThe Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsDaniel D. Lydiatt, DDS, MD¶Fred & Pamela Buffett Cancer CenterJane Messina, MD≠Moffitt Cancer CenterKishwer S. Nehal, MDϖ¶Memorial Sloan Kettering Cancer CenterPaul Nghiem, MD, PhDϖUniversity of Washington/Seattle Cancer Care AllianceIgor Puzanov, MD, MSCI‡Roswell Park Comprehensive Cancer CenterChrysalyne D. Schmults, MD, MSϖ¶Dana-Farber/Brigham and Women's Cancer CenterAshok R. Shaha, MD¶ζMemorial Sloan Kettering Cancer CenterValencia Thomas, MDϖThe University of Texas MD Anderson Cancer CenterYaohui G. Xu, MD, PhDϖUniversity of Wisconsin Carbone Cancer CenterJohn A. Zic, MDϖVanderbilt-Ingram Cancer CenterNCCN Staff: Karin G. Hoffmann, RN, CCM, and Anita M. Engh, PhDKEY:*Discussion Section Writing CommitteeSpecialties: ϖDermatology; ¶Surgery/Surgical Oncology; ζOtolaryngology; ≠Pathology/Dermatopathology; †Medical Oncology; ÞInternal Medicine; §Radiotherapy/Radiation Oncology; ŸReconstructive Surgery; ‡Hematology/Hematology Oncology
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