Soft Tissue Sarcoma, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

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Soft tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin that display a heterogenous mix of clinical and pathologic characteristics. STS can develop from fat, muscle, nerves, blood vessels, and other connective tissues. The evaluation and treatment of patients with STS requires a multidisciplinary team with demonstrated expertise in the management of these tumors. The complete NCCN Guidelines for STS provide recommendations for the diagnosis, evaluation, and treatment of extremity/superficial trunk/head and neck STS, as well as intra-abdominal/retroperitoneal STS, gastrointestinal stromal tumors, desmoid tumors, and rhabdomyosarcoma. This portion of the NCCN Guidelines discusses general principles for the diagnosis, staging, and treatment of STS of the extremities, superficial trunk, or head and neck; outlines treatment recommendations by disease stage; and reviews the evidence to support the guidelines recommendations.

Please Note

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) are a statement of consensus of the authors regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult the NCCN Guidelines® is expected to use independent medical judgment in the context of individual clinical circumstances to determine any patient's care or treatment. The National Comprehensive Cancer Network® (NCCN®) makes no representation or warranties of any kind regarding their content, use, or application and disclaims any responsibility for their applications or use in any way. The full NCCN Guidelines for Soft Tissue Sarcoma are not printed in this issue of JNCCN but can be accessed online at NCCN.org.

© National Comprehensive Cancer Network, Inc. 2018, All rights reserved. The NCCN Guidelines and the illustrations herein may not be reproduced in any form without the express written permission of NCCN.

Disclosures for the NCCN Soft Tissue Sarcoma Panel

At the beginning of each NCCN Guidelines panel meeting, panel members review all potential conflicts of interest. NCCN, in keeping with its commitment to public transparency, publishes these disclosures for panel members, staff, and NCCN itself.

Individual disclosures for the NCCN Soft Tissue Sarcoma Panel members can be found on page 563. (The most recent version of these guidelines and accompanying disclosures are available on the NCCN Web site at NCCN.org.)

These guidelines are also available on the Internet. For the latest update, visit NCCN.org.

NCCN Soft Tissue Sarcoma Screening Panel Members

*Margaret von Mehren, MD†/Chair

Fox Chase Cancer Center

*R. Lor Randall, MD¶τ/Vice-Chair

Huntsman Cancer Institute at the University of Utah

Robert S. Benjamin, MD†

The University of Texas MD Anderson Cancer Center

Sarah Boles, MD‡†

UC San Diego Moores Cancer Center

Marilyn M. Bui, MD, PhD≠

Moffitt Cancer Center

Kristen N. Ganjoo, MD†

Stanford Cancer Institute

Suzanne George, MD†

Dana-Farber/Brigham and Women's Cancer Center

Ricardo J. Gonzalez, MD¶

Moffitt Cancer Center

Martin J. Heslin, MD¶

University of Alabama at Birmingham Comprehensive Cancer Center

John M. Kane, III, MD¶

Roswell Park Comprehensive Cancer Center

Vicki Keedy, MD, MSCI†

Vanderbilt-Ingram Cancer Center

Edward Kim MD§

Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance

Henry Koon, MD†

Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute

Joel Mayerson, MD¶τ

The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute

Martin McCarter, MD¶

University of Colorado Cancer Center

Sean V. McGarry, MD¶τ

Fred & Pamela Buffett Cancer Center

Christian Meyer, MD, PhD†

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Zachary S. Morris, MD, PhD§

University of Wisconsin Carbone Cancer Center

Richard J. O'Donnell, MD¶

UCSF Helen Diller Family Comprehensive Cancer Center

Alberto S. Pappo, MD€

St. Jude Children's Research Hospital/The University of Tennessee Health Science Center

I. Benjamin Paz, MD¶

City of Hope Comprehensive Cancer Center

Ivy A. Petersen, MD§

Mayo Clinic Cancer Center

John D. Pfeifer, MD, PhD≠

Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine

Richard F. Riedel, MD†

Duke Cancer Institute

Bernice Ruo, MDÞ

Robert H. Lurie Comprehensive Cancer Center of Northwestern University

Scott Schuetze, MD, PhD†

University of Michigan Comprehensive Cancer Center

William D. Tap, MD†

Memorial Sloan Kettering Cancer Center

Jeffrey D. Wayne, MD¶

Robert H. Lurie Comprehensive Cancer Center of Northwestern University

NCCN Staff: Mary Anne Bergman, and Jillian L. Scavone, PhD

KEY:

*Discussion Section Writing Committee

Specialties: †Medical Oncology; ‡Hematology/Hematologic Oncology; ¶Surgery/Surgical Oncology; ÞInternal Medicine; τOrthopedics/Orthopedic Oncology; §Radiotherapy/Radiation Oncology; €Pediatric Oncology; ≠Pathology

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