NCCN Guidelines Insights: Thyroid Carcinoma, Version 2.2018

Authors:
Robert I. Haddad Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Christian Nasr Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Lindsay Bischoff Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Naifa Lamki Busaidy Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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David Byrd Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Glenda Callender Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Paxton Dickson Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Quan-Yang Duh Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Hormoz Ehya Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Whitney Goldner Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Megan Haymart Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Carl Hoh Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Jason P. Hunt Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Andrei Iagaru Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Fouad Kandeel Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Peter Kopp Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Dominick M. Lamonica Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Bryan McIver Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Christopher D. Raeburn Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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John A. Ridge Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Matthew D. Ringel Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Randall P. Scheri Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Jatin P. Shah Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Rebecca Sippel Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Robert C. Smallridge Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Cord Sturgeon Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Thomas N. Wang Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Lori J. Wirth Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Richard J. Wong Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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 MD
,
Alyse Johnson-Chilla Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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 MS
,
Karin G. Hoffmann Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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 RN, CCM
, and
Lisa A. Gurski Dana-Farber/Brigham and Women's Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Vanderbilt-Ingram Cancer Center; The University of Texas MD Anderson Cancer Center; University of Washington/Seattle Cancer Care Alliance; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UCSF Helen Diller Family Comprehensive Cancer Center; Fox Chase Cancer Center; Fred & Pamela Buffett Cancer Center; University of Michigan Rogel Cancer Center; UC San Diego Moores Cancer Center; Huntsman Cancer Institute at the University of Utah; Stanford Cancer Institute; City of Hope National Medical Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Roswell Park Comprehensive Cancer Center; Moffitt Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute; Duke Cancer Institute; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Mayo Clinic Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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 PhD
Volume/Issue:
Volume 16: Issue 12
Online Publication Date:
Dec 2018
DOI:
https://doi.org/10.6004/jnccn.2018.0089
Restricted access

The NCCN Guidelines for Thyroid Carcinoma provide recommendations for the management of different types of thyroid carcinoma, including papillary, follicular, Hürthle cell, medullary, and anaplastic carcinomas. These NCCN Guidelines Insights summarize the panel discussion behind recent updates to the guidelines, including the expanding role of molecular testing for differentiated thyroid carcinoma, implications of the new pathologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features, and the addition of a new targeted therapy option for BRAF V600E–mutated anaplastic thyroid carcinoma.

Provided content development and/or authorship assistance.

Please Note

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) are a statement of consensus of the authors regarding their views of currently accepted approaches to treatment. The NCCN Guidelines® Insights highlight important changes in the NCCN Guidelines® recommendations from previous versions. Colored markings in the algorithm show changes and the discussion aims to further understanding of these changes by summarizing salient portions of the panel's discussion, including the literature reviewed.

The NCCN Guidelines Insights do not represent the full NCCN Guidelines; further, the National Comprehensive Cancer Network® (NCCN®) makes no representation or warranties of any kind regarding the content, use, or application of the NCCN Guidelines and NCCN Guidelines Insights and disclaims any responsibility for their applications or use in any way.

The full and most current version of these NCCN Guidelines is available at NCCN.org.

© National Comprehensive Cancer Network, Inc. 2018, All rights reserved. The NCCN Guidelines and the illustrations herein may not be reproduced in any form without the express written permission of NCCN.

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    U.S. Food & Drug Administration. FDA approves dabrafenib plus trametinib for anaplastic thyroid cancer with BRAF V600E mutation. Available at: https://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm606708.htm. Accessed August 24, 2018.

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Copyright:
Copyright © 2018 by the National Comprehensive Cancer Network 2018
Page Numbers:
12
Article Category:
Research Article
Print Publication Date:
01 Dec 2018
Online Publication Date:
Dec 2018
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