NCCN Guidelines Insights: Multiple Myeloma, Version 3.2018

Authors:
Shaji K. Kumar From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Natalie S. Callander From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Melissa Alsina From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Djordje Atanackovic From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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J. Sybil Biermann From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Jorge Castillo From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Jason C. Chandler From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Caitlin Costello From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Matthew Faiman From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Henry C. Fung From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Kelly Godby From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Craig Hofmeister From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Leona Holmberg From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Sarah Holstein From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Carol Ann Huff From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Yubin Kang From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Adetola Kassim From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Michaela Liedtke From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Ehsan Malek From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Thomas Martin From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Vishala T. Neppalli From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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James Omel From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Noopur Raje From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Seema Singhal From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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George Somlo From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Keith Stockerl-Goldstein From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Donna Weber From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Joachim Yahalom From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Rashmi Kumar From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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Dorothy A. Shead From Mayo Clinic Cancer Center; University of Wisconsin Carbone Cancer Center; Moffitt Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Comprehensive Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; UC San Diego Moores Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Fox Chase Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fred & Pamela Buffett Cancer Center University of Nebraska Medical Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Cancer Institute; Patient Advocate; Massachusetts General Hospital Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; and National Comprehensive Cancer Network.

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The NCCN Guidelines for Multiple Myeloma provide recommendations for diagnosis, evaluation, treatment, including supportive-care, and follow-up for patients with myeloma. These NCCN Guidelines Insights highlight the important updates/changes specific to the myeloma therapy options in the 2018 version of the NCCN Guidelines.

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