Counterpoint: Successes in the Pursuit of Precision Medicine: Biomarkers Take Credit

Authors:
Shumei Kato
Search for other papers by Shumei Kato in
Current site
Google Scholar
PubMed
Close
 MD
,
Vivek Subbiah
Search for other papers by Vivek Subbiah in
Current site
Google Scholar
PubMed
Close
 MD
, and
Razelle Kurzrock
Search for other papers by Razelle Kurzrock in
Current site
Google Scholar
PubMed
Close
 MD
Restricted access

Dr. Kato is an Assistant Professor of Medicine at University of California, San Diego. He treats a wide variety of cancers, including gastrointestinal cancer and rare tumors. His research focus is investigating the novel targeted therapy approach as well as understanding the resistant mechanism from targeted agents.

The ideas and viewpoints expressed in this commentary are those of the author and do not necessarily represent any policy, position, or program of NCCN.

Dr. Subbiah, a clinical trials investigator, is currently an Assistant Professor in the Department of Investigational Cancer Therapeutics (A Phase 1 Program), Division of Cancer Medicine, at The University of Texas MD Anderson Cancer Center. Dr. Subbiah has a unique training background in that he is one of the few physicians in the nation to have training in oncology in both adults and children. He is primarily involved in translational cancer research and the design/conduct of early-phase, biomarker-driven clinical trials, with a special interest in precision oncology and immunoconjugate trials. He is a major advocate for precision oncology and personalized medicine.

Dr. Subbiah receives research funding for clinical trials from Roche/Genentech, Novartis, Bayer, GSK, Nanocarrier, Vegenics, Northwest Biotherapeutics, Berghealth, Incyte, Fujifilm, Pharmamar, D3, Pfizer, Multivir, Amgen, Abbvie, and Bluprint Medicines.

Dr. Kurzrock is a Senior Deputy Director, UCSD Moores Cancer Center; Director, Center for Personalized Cancer Therapy and Clinical Trial Office; and Chief, Division of Hematology and Oncology at University of California, San Diego. She developed the largest phase I clinical trials department in the world at The University of Texas MD Anderson Cancer Center before being appointed at University of California, San Diego. At the Center for Personalized Cancer Therapy, she uses advanced molecular technologies to match patients with cancer with genomically targeted therapies and immunotherapy to optimize the chance for response.

She receives consultant fees from X-biotech and from Actuate Therapeutics, as well as research funds from Genentech, Pfizer, Sequenom, Guardant, Foundation Medicine, and Merck Serono, and has an ownership interest in CureMatch Inc.

  • Collapse
  • Expand
  • 1.

    Le Tourneau C, Delord JP, Goncalves A et al.. Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial. Lancet Oncol 2015;16:13241334.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Garay JP, Gray JW. Omics and therapy - a basis for precision medicine. Mol Oncol 2012;6:128139.

  • 3.

    Schwaederle M, Zhao M, Lee JJ et al.. Association of biomarker-based treatment strategies with response rates and progression-free survival in refractory malignant neoplasms: a meta-analysis. JAMA Oncol 2016;2:14521459.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Hyman DM, Puzanov I, Subbiah V et al.. Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations. N Engl J Med 2015;373:726736.

  • 5.

    Wheler JJ, Janku F, Naing A et al.. Cancer therapy directed by comprehensive genomic profiling: a single center study. Cancer Res 2016;76:36903701.

  • 6.

    Jardim DL, Schwaederle M, Wei C et al.. Impact of a biomarker-based strategy on oncology drug development: a meta-analysis of clinical trials leading to FDA approval. J Natl Cancer Inst 2015;107. pii: djv253.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Schwaederle M, Zhao M, Lee JJ et al.. Impact of precision medicine indiverse cancers: a meta-analysis of phase II clinical trials. J Clin Oncol 2015;33:38173325.

  • 8.

    Patel SP, Kurzrock R. PD-L1 expression as a predictive biomarker in cancer immunotherapy. Mol Cancer Ther 2015;14:847856.

  • 9.

    Subbiah V, Kurzrock R. Universal genomic testing needed to win the war against cancer: genomics IS the diagnosis. JAMA Oncol 2016;2:719720.

Metrics

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 1632 677 36
PDF Downloads 640 148 13
EPUB Downloads 0 0 0