NCCN Guidelines Insights: Hepatobiliary Cancers, Version 1.2017

Authors:
Al B. Benson III From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Michael I. D'Angelica From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Daniel E. Abbott From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Thomas A. Abrams From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Steven R. Alberts From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Daniel A. Anaya From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Chandrakanth Are From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Daniel B. Brown From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Daniel T. Chang From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Anne M. Covey From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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William Hawkins From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Renuka Iyer From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Rojymon Jacob From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Andrea Karachristos From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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R. Kate Kelley From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Robin Kim From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Manisha Palta From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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James O. Park From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Vaibhav Sahai From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Tracey Schefter From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Carl Schmidt From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Jason K. Sicklick From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Gagandeep Singh From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Davendra Sohal From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Stacey Stein From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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G. Gary Tian From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Jean-Nicolas Vauthey From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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 MD
,
Alan P. Venook From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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,
Andrew X. Zhu From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Karin G. Hoffmann From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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Susan Darlow From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Memorial Sloan Kettering Cancer Center; University of Wisconsin Carbone Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Mayo Clinic Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Vanderbilt-Ingram Cancer Center; Stanford Cancer Institute; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; University of Alabama at Birmingham Comprehensive Cancer Center; Fox Chase Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; Huntsman Cancer Institute at the University of Utah; Duke Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Michigan Comprehensive Cancer Center; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; UC San Diego Moores Cancer Center; City of Hope Comprehensive Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Yale Cancer Center/Smilow Cancer Hospital; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; and National Comprehensive Cancer Network.

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 PhD
Volume/Issue:
Volume 15: Issue 5
Online Publication Date:
May 2017
DOI:
https://doi.org/10.6004/jnccn.2017.0059
Restricted access

The NCCN Guidelines for Hepatobiliary Cancers provide treatment recommendations for cancers of the liver, gallbladder, and bile ducts. The NCCN Hepatobiliary Cancers Panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding locoregional therapy for treatment of patients with hepatocellular carcinoma.

Provided content development and/or authorship assistance.

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Print ISSN:
1540-1405
Online ISSN:
1540-1413
Publisher:
National Comprehensive Cancer Network
Cover Journal of the National Comprehensive Cancer Network
Copyright:
Copyright © 2017 by the National Comprehensive Cancer Network 2017
Page Numbers:
11
Article Category:
Research Article
Print Publication Date:
01 May 2017
Online Publication Date:
May 2017

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