The Call of “The Wild”-Type GIST: It's Time for Domestication

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Maha Alkhuziem, MBBS, MAS, is a Postdoctoral Research Fellow in the Department of Surgery at the UC San Diego Moores Cancer Center. Her research interests in Dr. Sicklick's laboratory include novel therapeutic strategies for gastrointestinal stromal tumors (GIST) and postoperative ileus.

Adam M. Burgoyne, MD, PhD, is an Instructor of Medicine in the Division of Hematology-Oncology at the UC San Diego Moores Cancer Center. He is a physician-scientist with research interests including characterization of the tumor microenvironment of GIST and rational drug design of targeted therapeutics for personalized therapy of hepatocellular carcinoma.

The ideas and viewpoints expressed in this commentary are those of the author and do not necessarily represent any policy, position, or program of NCCN.

Paul T. Fanta, MD, is an Associate Professor of Medicine in the Division of Hematology-Oncology at the UC San Diego Moores Cancer Center. His research interests include incorporating biotechnology, bioinformatics, molecular analyses, and pharmocogenomic data in the setting of prospective clinical trials, with the goal of increasing benefit from chemotherapy, avoiding toxicities from treatment, and developing a predictive therapeutic strategy unique to each patient's disease.

Chih-Min Tang, PhD, is a Research Associate in the Department of Surgery at the UC San Diego Moores Cancer Center. Dr. Tang completed a postdoctoral fellowship in pharmacogenomics in the Department of Pharmacology at UC San Diego School of Medicine. She is currently using in vitro and in vivo models to investigate mechanisms of GIST drug resistance in GIST.

Jason K. Sicklick, MD, is an Associate Professor of Surgery in the Division of Surgical Oncology at the UC San Diego Moores Cancer Center. He is a surgical oncologist specializing in the treatment of sarcomas, including GIST, and hepatobiliary diseases. In 2016, Dr. Sicklick was named the GIST Clinician of the Year by the Life Raft GIST Support Group, an international GIST patient advocacy group. Dr. Sicklick is a member of the NCI's GIST Working Group, the NCCN Hepatobiliary Cancers Panel, and the Transatlantic Atlantic Retroperitoneal Sarcoma Working Group. He is an NIH-funded surgeon-scientist with a translational and clinical research focus on molecular mechanisms of GIST and hepatocellular carcinoma, as well as precision medicine approaches to cancer therapy.

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