NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2017

Authors:
Mary B. Daly From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Robert Pilarski From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Michael Berry From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Saundra S. Buys From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Meagan Farmer From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Susan Friedman From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Judy E. Garber From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Noah D. Kauff From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Seema Khan From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Catherine Klein From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Wendy Kohlmann From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Allison Kurian From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Jennifer K. Litton From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Lisa Madlensky From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Sofia D. Merajver From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Kenneth Offit From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Tuya Pal From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Gwen Reiser From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Kristen Mahoney Shannon From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Elizabeth Swisher From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Shaveta Vinayak From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Nicoleta C. Voian From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Jeffrey N. Weitzel From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Myra J. Wick From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Georgia L. Wiesner From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Mary Dwyer From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Susan Darlow From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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The NCCN Clinical Practice Guidelines in Oncology for Genetic/Familial High-Risk Assessment: Breast and Ovarian provide recommendations for genetic testing and counseling for hereditary cancer syndromes and risk management recommendations for patients who are diagnosed with a syndrome. Guidelines focus on syndromes associated with an increased risk of breast and/or ovarian cancer. The NCCN Genetic/Familial High-Risk Assessment: Breast and Ovarian panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. The NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding risk management for carriers of moderately penetrant genetic mutations associated with breast and/or ovarian cancer.

Provided content development and/or authorship assistance.

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