NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2017

Authors:
Mary B. DalyFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Robert PilarskiFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Michael BerryFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Saundra S. BuysFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Meagan FarmerFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Susan FriedmanFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Judy E. GarberFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Noah D. KauffFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Seema KhanFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Catherine KleinFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Wendy KohlmannFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Allison KurianFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Jennifer K. LittonFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Lisa MadlenskyFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Sofia D. MerajverFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Kenneth OffitFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Tuya PalFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Gwen ReiserFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Kristen Mahoney ShannonFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Elizabeth SwisherFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Shaveta VinayakFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Nicoleta C. VoianFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Jeffrey N. WeitzelFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Myra J. WickFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Georgia L. WiesnerFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Mary DwyerFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Susan DarlowFrom Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE: Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center;Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center;Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Volume/Issue:
Volume 15: Issue 1
Online Publication Date:
Jan 2017
DOI:
https://doi.org/10.6004/jnccn.2017.0003
Restricted access

The NCCN Clinical Practice Guidelines in Oncology for Genetic/Familial High-Risk Assessment: Breast and Ovarian provide recommendations for genetic testing and counseling for hereditary cancer syndromes and risk management recommendations for patients who are diagnosed with a syndrome. Guidelines focus on syndromes associated with an increased risk of breast and/or ovarian cancer. The NCCN Genetic/Familial High-Risk Assessment: Breast and Ovarian panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. The NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding risk management for carriers of moderately penetrant genetic mutations associated with breast and/or ovarian cancer.

Provided content development and/or authorship assistance.

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Copyright:
Copyright © 2017 by the National Comprehensive Cancer Network 2017
Page Numbers:
12
Article Category:
Research Article
Print Publication Date:
01 Jan 2017
Online Publication Date:
Jan 2017
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