Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2015

Authors:
Mary B. Daly From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Robert Pilarski From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Jennifer E. Axilbund From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Michael Berry From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Saundra S. Buys From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Beth Crawford From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Meagan Farmer From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Susan Friedman From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Judy E. Garber From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Seema Khan From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Catherine Klein From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Wendy Kohlmann From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Allison Kurian From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Jennifer K. Litton From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Lisa Madlensky From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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P. Kelly Marcom From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Sofia D. Merajver From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Kenneth Offit From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Tuya Pal From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Huma Rana From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Gwen Reiser From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Mark E. Robson From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Kristen Mahoney Shannon From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Elizabeth Swisher From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Nicoleta C. Voian From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Jeffrey N. Weitzel From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Alison Whelan From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Myra J. Wick From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Georgia L. Wiesner From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Mary Dwyer From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Rashmi Kumar From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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Susan Darlow From Fox Chase Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Huntsman Cancer Institute at the University of Utah; UCSF Helen Diller Family Comprehensive Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; FORCE-Facing Our Risk of Cancer Empowered; Dana-Farber/Brigham and Women's Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Colorado Cancer Center; Stanford Cancer Institute; The University of Texas MD Anderson Cancer Center; UC San Diego Moores Cancer Center; Duke Cancer Institute; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Moffitt Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; University of Washington Medical Center/Seattle Cancer Care Alliance; Roswell Park Cancer Institute; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Vanderbilt-Ingram Cancer Center; and National Comprehensive Cancer Network.

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The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast and Ovarian provide recommendations for genetic testing and counseling and risk assessment and management for hereditary cancer syndromes. Guidelines focus on syndromes associated with an increased risk of breast and/or ovarian cancer and are intended to assist with clinical and shared decision-making. These NCCN Guidelines Insights summarize major discussion points of the 2015 NCCN Genetic/Familial High-Risk Assessment: Breast and Ovarian panel meeting. Major discussion topics this year included multigene testing, risk management recommendations for less common genetic mutations, and salpingectomy for ovarian cancer risk reduction. The panel also discussed revisions to genetic testing criteria that take into account ovarian cancer histology and personal history of pancreatic cancer.

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