Dr. Rajan had disclosed that he is a consultant for Baxter International Inc., Alexion Pharmaceuticals, Biogen Idec, and Incyte Corporation; he receives honoraria from Alexion Pharmaceuticals; is on the speakers’ bureau for Alexion Pharmaceuticals and Biogen Idec; and receives research support from Incyte Corporation. Dr. Armitage has disclosed that he is a consultant for Celgene Corporation, GlaxoSmithKline, Roche, Spectrum Pharmaceuticals, Inc., and ZIOPHARM Oncology, Inc; and is on the Board of Directors for TESARO, Inc. The remaining authors have disclosed that they have no financial interests, arrangements, affiliations, or commercial interests with the manufacturers of any products discussed in this article or their competitors.
Kerrin M. Green, MA,Assistant Managing Editor, JNCCN—Journal of the National Comprehensive Cancer Network
Ms. Green has disclosed that she has no relevant financial relationships.
Deborah J. Moonan, RN, BSN, Director, Continuing Education, has disclosed that she has no relevant financial relationships.
Ann Gianola, MA, Manager, Continuing Education Accreditation & Program Operations, has disclosed that she has no relevant financial relationships.
Kristina M. Gregory, RN, MSN, OCN, Vice President, Clinical Information Operations, has disclosed that she has no relevant financial relationships.
Rashmi Kumar, PhD, Senior Manager, Clinical Content, has disclosed that she has no relevant financial relationships.
Hema Sundar, PhD, Oncology Scientist/Senior Medical Writer, has disclosed that she has no relevant financial relationships.
The authors would like to thank Christine Higgins and Pamela Althof for their help in conducting cytogenetic and fluorescence in situ hybridization studies.
TefferiA. Polycythemia vera and essential thrombocythemia: 2012 update on diagnosis, risk stratification, and management. Am J Hematol2012;87:285–293.
GangatNWolanskyjAPMcClureRF. Risk stratification for survival and leukemic transformation in essential thrombocythemia: a single institutional study of 605 patients. Leukemia2007;21:270–276.
WolanskyjAPSchwagerSMMcClureRF. Essential thrombocythemia beyond the first decade: life expectancy, long-term complication rates, and prognostic factors. Mayo Clin Proc2006;81:159–166.
ChimCSKwongYLLieAK. Long-term outcome of 231 patients with essential thrombocythemia: prognostic factors for thrombosis, bleeding, myelofibrosis, and leukemia. Arch Intern Med2005;165:2651–2658.
Muringampurath-JohnDJayeDLFlowersCR. Characteristics and outcomes of diffuse large B-cell lymphoma presenting in leukaemic phase. Br J Haematol2012;158:608–614.
FrederiksenHFarkasDKChristiansenCF. Chronic myeloproliferative neoplasms and subsequent cancer risk: a Danish population-based cohort study. Blood2011;118:6515–6520.
VannucchiAMMasalaGAntonioliE. Increased risk of lymphoid neoplasms in patients with Philadelphia chromosome-negative myeloproliferative neoplasms. Cancer Epidemiol Biomarkers Prev2009;18:2068–2073.
LarsenTSChristensenJHHasselbalchHCPallisgaardN. The JAK2 V617F mutation involves B- and T-lymphocyte lineages in a subgroup of patients with Philadelphia-chromosome negative chronic myeloproliferative disorders. Br J Haematol2007;136:745–751.
TefferiAVaidyaRCaramazzaD. Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels are independently prognostic in primary myelofibrosis: a comprehensive cytokine profiling study. J Clin Oncol2011;29:1356–1363.
PalandriFCataniLTestoniN. Long-term follow-up of 386 consecutive patients with essential thrombocythemia: safety of cytoreductive therapy. Am J Hematol2009;84:215–220.
HarrisonCKiladjianJJAl-AliHK. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med2012;366:787–798.
TefferiAPardananiA. Serious adverse events during ruxolitinib treatment discontinuation in patients with myelofibrosis. Mayo Clin Proc2011;86:1188–1191.
VerstovsekSKantarjianHMesaRA. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. New Engl J Med2010;363:1117–1127.
CuttnerJWallensteinSTroyK. Non-Hodgkin’s lymphoma in patients 70 years of age or older: factors associated with survival. Leuk Res2002;26:447–450.
PalandriFDerenziniEOttavianiE. Association of essential thrombocythemia and non-Hodgkin lymphoma: a single-centre experience. Leuk Lymphoma2009;50:481–484.