The activating BRAF mutation p.V600E has been identified in many cancers, including colon and lung adenocarcinomas, papillary thyroid cancer, malignant melanoma, and hairy cell leukemia (HCL). Malignant melanoma and HCL are of particular interest because of both the high proportion of cases harboring the mutation and the dramatic responses to BRAF inhibitor therapy reported in the literature. This report presents a patient with HCL and malignant melanoma with the BRAF p.V600E mutation, and discusses the successful treatment of both cancers with the BRAF inhibitor dabrafenib.
Correspondence: Leslie A. Andritsos, MD, The Ohio State University, Division of Hematology, Department of Internal Medicine, B352 Starling-Loving Hall, 320 West 10th Avenue, Columbus, OH 43210. E-mail: Leslie.Andritsos@osumc.edu