Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 1.2014

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Mary B. Daly
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Robert Pilarski
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Jennifer E. Axilbund
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Saundra S. Buys
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Beth Crawford
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Susan Friedman
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Judy E. Garber
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Carolyn Horton
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Virginia Kaklamani
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Catherine Klein
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Wendy Kohlmann
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Allison Kurian
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Jennifer Litton
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Lisa Madlensky
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P. Kelly Marcom
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Sofia D. Merajver
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Kenneth Offit
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Tuya Pal
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Boris Pasche
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Gwen Reiser
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Kristen Mahoney Shannon
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Elizabeth Swisher
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Nicoleta C. Voian
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Jeffrey N. Weitzel
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Alison Whelan
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Georgia L. Wiesner
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Mary A. Dwyer
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Rashmi Kumar
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During the past few years, several genetic aberrations that may contribute to increased risks for development of breast and/or ovarian cancers have been identified. The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast and Ovarian focus specifically on the assessment of genetic mutations in BRCA1/BRCA2, TP53, and PTEN, and recommend approaches to genetic testing/counseling and management strategies in individuals with these mutations. This portion of the NCCN Guidelines includes recommendations regarding diagnostic criteria and management of patients with Cowden Syndrome/PTEN hamartoma tumor syndrome.

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