Treatment Strategies for Myeloid Growth Factors and Intravenous Iron: When, What, and How?

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Myeloid growth factors can reduce the risk of chemotherapy-induced neutropenia (CIN) and thus impact the survival of patients with cancer. Patients should be assessed for risk, taking into consideration patient-related risk factors and chemotherapy regimens. Patients stratified as having at least a 20% risk for CIN should be considered for prophylactic growth factors. The NCCN Guidelines for Myeloid Growth Factors provide category 1 recommendations for the daily use of filgrastim, tbo-filgrastim, and pegfilgrastim. Cancer-related anemia can be treated with erythropoiesis-stimulating agents, red blood cell transfusion, or intravenous iron.

Correspondence: Jeffrey Crawford, MD, Duke Cancer Institute, Duke University Medical Center, 441 Seeley G. Mudd Building, 10 Bryan Searle Drive, Box 3476, Durham, NC 27710. E-mail: crawf006@mc.duke.eduCorrespondence: George M. Rodgers, MD, PhD, Huntsman Cancer Institute at the University of Utah, Division of Hematology, University of Utah Medical Center, 30 North 1900 East, Rm 5C-402, Salt Lake City, UT 84132. E-mail: george.rodgers@hsc.utah.edu
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