“Screening for prostate cancer has been a public health disaster,” announced Andrew J. Vickers, PhD, Attending Research Methodologist, Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York City. At the center of the debate is the question of whether the benefits of prostate-specific antigen (PSA) screening (namely the reduction in mortality) outweigh the harms (overdiagnosis and overtreatment). According to Dr. Vickers and his colleague Peter R. Carroll, MD, MPH, Professor and Chair, Department of Urology, University of California, San Francisco, the answer depends on screening younger men than in the past, adherence to strict criteria for biopsy, aggressive treatment of men with high-risk disease, and active surveillance for men with low-risk disease. Both Drs. Carroll and Vickers are members of the NCCN Guidelines Panel for Prostate Cancer Early Detection.
Dr. Carroll has disclosed that he has received grants or research support from Genomic Health, Inc., and consulting fees or honoraria from Intuitive Surgical, Inc., Jannsen Pharmaceutica Products, LP, Takeda Pharmaceuticals North America, Inc., and TEVA. Dr. Vickers has disclosed that he has received grants or research support from GlaxoSmithKline, royalty income from Arctic Partners, and has served as scientific advisor for Genomic Health, Inc., Genome DX, Ringful Health.
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